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Botulinum Neurotoxin Type B (BoNT/B) antibody
Alternatives Flow Cytometry (FACS), Cell-ELISA (cELISA)
|4 references available|
|Quantity||100 ug (2 mg/ml)|
|Price||663.77 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 6 Business Days|
|Immunogen||genetic immunisation with cDNA encoding BoNT/B|
|Description||Botulinum neurotoxin type B (BoNT/B) is produced by Clostridium botulinum, a genetically diverse class of anaerobic, spore-forming, gram-positive bacilli. Seven different botulinum toxin groups have been identified serologically and are called botulinum toxin type A,B,C1,D,E,F, and G (1). BoNT/B is a two-chain polypeptide with a 100-kDa heavy chain, which is responsible for neurospecific binding joined by a disulphide bond to a 50-kDa light chain, a zinc-endopeptidase which blocks neurotransmitter release (2,3). BoNT/B is one of the most poisonous naturally occurring substances. It inhibits acetylcholine release from neuromuscular junctions while it is used as an important therapeutic mainstay in the treatment of spasticity disorders and as a cosmetic treatment (4).|
|Application Notes||FACS: 1.2ug/10^6 cells, Cell-ELISA: 1:200 to 1:400|
|Buffer||phosphate buffered saline, pH 7.2|
|Storage||Short term: 2°C - 8°C. long term: -20°C (avoid repeated freezing and thawing)|
|Restrictions||For Research Use only|
Schiavo, Benfenati, Poulain et al.: "Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin." in: Nature, Vol. 359, Issue 6398, pp. 832-5, 1992 (PubMed).
DasGupta: "Structure and biological activity of botulinum neurotoxin." in: Journal de physiologie, Vol. 84, Issue 3, pp. 220-8, 1991 (PubMed).
Tonello, Morante, Rossetto et al.: "Tetanus and botulism neurotoxins: a novel group of zinc-endopeptidases." in: Advances in experimental medicine and biology, Vol. 389, pp. 251-60, 1997 (PubMed).
Papapetropoulos, Singer: "Botulinum toxin in movement disorders." in: Seminars in neurology, Vol. 27, Issue 2, pp. 183-94, 2007 (PubMed).