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Details for Product No. ABIN182475

SMAD, Mothers Against DPP Homolog 7 (SMAD7) (N-Term) antibody

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Antigen
Synonyms Smad10, madh7, xsmad7, CRCS3, MADH7, MADH8, Smad7a, Madh7
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Dog (Canine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN182475
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-SMAD7 antibody: synthetic peptide directed towards the N terminal of human SMAD7
Sequence EEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLG KAVRGAKGHH
Predicted Reactivity Human : 100%, Bovine : 92%, Dog : 92%, Mouse : 92%, Pig : 92%, Rat : 84%
Characteristics This is a rabbit polyclonal antibody against SMAD7. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name SMAD7
Background Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition.
Molecular Weight 46kDa
Gene ID 4092
NCBI Accession NP_005895, NM_005904
UniProt O15105
Research Area Signaling, Transcription Factors
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-SMAD7 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Komuro, Imamura, Saitoh et al.: "Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)." in: Oncogene, Vol. 23, Issue 41, pp. 6914-23, 2004 (PubMed).

Alternatives for antigen "SMAD, Mothers Against DPP Homolog 7 (SMAD7)", type "Antibodies"
Hosts (26), (19)
Reactivities (45), (10), (10), (1), (1), (1), (1), (1), (1)
Applications (43), (22), (10), (7), (4), (2), (1), (1)
Epitopes (10), (4), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1)
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