SMAD, Mothers Against DPP Homolog 7 (SMAD7) (N-Term) antibody

Details for Product No. ABIN182475
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Antigen
Synonyms Smad10, madh7, xsmad7, CRCS3, MADH7, MADH8, Smad7a, Madh7
Epitope
N-Term
(10), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Human
(49), (14), (13), (1), (1)
Host
Rabbit
(31), (21)
Clonality
Polyclonal
Application
Western Blotting (WB)
(50), (26), (13), (7), (5), (5), (4), (2), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN182475
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide directed towards the N terminal of human SMAD7
Sequence EEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLG KAVRGAKGHH
Predicted Reactivity Human : 100 %, Bovine : 90 %, Dog : 90 %, Mouse : 90 %, Pig : 90 %, Rat : 80 %
Characteristics This is a rabbit polyclonal antibody against SMAD7. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SMAD7
Background Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition.
Molecular Weight 46 kDa
Gene ID 4092
NCBI Accession NM_005904, NP_005895
UniProt O15105
Research Area Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 426 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-SMAD, Mothers Against DPP Homolog 7 (SMAD7) (N-Term) antibody anti-SMAD, Mothers Against DPP Homolog 7 (SMAD7) (N-Term) antibody
Background publications Komuro, Imamura, Saitoh et al.: "Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)." in: Oncogene, Vol. 23, Issue 41, pp. 6914-23, 2004 (PubMed).

Hosts (31), (21)
Reactivities (49), (14), (13), (1), (1)
Applications (50), (26), (13), (7), (5), (5), (4), (2), (1), (1)
Epitopes (10), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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