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SMAD7 antibody (N-Term)

SMAD7 Reactivity: Human, Mouse, Rat, Pig, Cow, Dog, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN182475
  • Target See all SMAD7 Antibodies
    SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))
    Binding Specificity
    • 17
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 46
    • 26
    • 24
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Pig, Cow, Dog, Rabbit
    Host
    • 39
    • 7
    Rabbit
    Clonality
    • 40
    • 6
    Polyclonal
    Conjugate
    • 29
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SMAD7 antibody is un-conjugated
    Application
    • 26
    • 17
    • 14
    • 14
    • 10
    • 8
    • 8
    • 4
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    EEEGAGGGGG GGELRGEGAT DSRAHGAGGG GPGRAGCCLG KAVRGAKGHH
    Predicted Reactivity
    Cow: 93%, Dog: 93%, Human: 100%, Mouse: 92%, Pig: 93%, Rabbit: 93%, Rat: 85%
    Characteristics
    This is a rabbit polyclonal antibody against SMAD7. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD7
    Top Product
    Discover our top product SMAD7 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 426 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))
    Alternative Name
    SMAD7 (SMAD7 Products)
    Synonyms
    CRCS3 antibody, MADH7 antibody, MADH8 antibody, Smad7a antibody, Madh7 antibody, Smad10 antibody, madh7 antibody, xsmad7 antibody, wu:fj60c10 antibody, SMAD family member 7 antibody, SMAD family member 7 L homeolog antibody, SMAD7 antibody, Smad7 antibody, smad7.L antibody, smad7 antibody
    Background
    Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition.
    Alias Symbols: CRCS3, MADH7, MADH8
    Protein Interaction Partner: HDAC3, HDAC2, USP11, SMURF2, SMURF1, SKP2, MYC, Melk, HCVgp1, RNF111, KDM2A, SOX13, PIAS1, SOX7, UBE2O, MKL2, ASH1L, PIAS4, CXXC5, ZNF107, ZBTB11, HEYL, TTF2, UBC, TTF1, SOX5, MYOD1, XRCC6, CTNNB1, MAPK14, BAMBI, PPP1R15A, NEDD4L, STAMBP, YAP1, AXIN1, TP5
    Protein Size: 426
    Molecular Weight
    46 kDa
    Gene ID
    4092
    NCBI Accession
    NM_005904, NP_005895
    UniProt
    O15105
    Pathways
    Interferon-gamma Pathway, Cell-Cell Junction Organization
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