Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4) (C-Term) antibody

Details for Product No. ABIN182537
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Antigen
Synonyms
Af1, Mcb1, angiocidin, af-1, mcb1, pub-r5, rpn10, xrpn10c, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, psmd4, im:6912672, wu:fc68c04, zgc:110247, PSMD4, DDBDRAFT_0202512, DDBDRAFT_0232981, DDB_0202512, D ... show more
Af1, Mcb1, angiocidin, af-1, mcb1, pub-r5, rpn10, xrpn10c, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, psmd4, im:6912672, wu:fc68c04, zgc:110247, PSMD4, DDBDRAFT_0202512, DDBDRAFT_0232981, DDB_0202512, DDB_0232981 show less
Epitope
C-Term
(4), (4), (3), (1), (1)
Reactivity
Rabbit, Rat (Rattus), Mouse (Murine), Pig (Porcine), Cow (Bovine), Xenopus laevis, Human
(27), (11), (8), (2), (2), (2), (2), (1), (1), (1)
Host
Rabbit
(26), (3), (1)
Clonality
Polyclonal
Application
Western Blotting (WB)
(29), (9), (8), (6), (3), (1)
Pubmed 1 reference available
Catalog no. ABIN182537
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide directed towards the C terminal of human PSMD4
Sequence VMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDG KKDKKEEDKK
Predicted Reactivity Bovine : 100 %, Human : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Sheep : 100 %, Mouse : 90 %, African clawed frog : 80 %
Characteristics This is a rabbit polyclonal antibody against PSMD4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PSMD4
Background The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD4 encodes one of the non-ATPase subunits of the 19S regulator lid.
Molecular Weight 41 kDa
Gene ID 5710
NCBI Accession NM_002810, NP_002801
UniProt P55036
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 377 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4) (C-Term) antibody WB Suggested Anti-PSMD4 Antibody Titration: 0.2-1 ug/ml
Positive Control: Raji cell lysate
Background publications Fujiwara, Tenno, Sugasawa et al.: "Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B." in: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4760-7, 2004 (PubMed).

Hosts (26), (3), (1)
Reactivities (27), (11), (8), (2), (2), (2), (2), (1), (1), (1)
Applications (29), (9), (8), (6), (3), (1)
Epitopes (4), (4), (3), (1), (1)
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