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Details for Product No. ABIN182537

Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4) (C-Term) antibody

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Antigen
Synonyms
Af1, Mcb1, angiocidin, af-1, mcb1, pub-r5, rpn10, xrpn10c, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, psmd4, im:6912672, wu:fc68c04, zgc:110247, PSMD4, DDBDRAFT_0202512, DDBDRAFT_0232981, DDB_0202512, D ... show more
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Rabbit, Rat (Rattus), Mouse (Murine), Pig (Porcine), Cow (Bovine), Xenopus laevis, Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN182537
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-PSMD4 antibody: synthetic peptide directed towards the C terminal of human PSMD4
Sequence VMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDG KKDKKEEDKK
Predicted Reactivity Bovine : 100%, Human : 100%, Pig : 100%, Rabbit : 100%, Rat : 100%, Sheep : 100%, Mouse : 92%, African clawed frog : 85%
Characteristics This is a rabbit polyclonal antibody against PSMD4. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name PSMD4
Background The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD4 encodes one of the non-ATPase subunits of the 19S regulator lid.
Molecular Weight 41kDa
Gene ID 5710
NCBI Accession NP_002801, NM_002810
UniProt P55036
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-PSMD4 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Fujiwara, Tenno, Sugasawa et al.: "Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B." in: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4760-7, 2004 (PubMed).

Alternatives for antigen "Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4)", type "Antibodies"
Hosts (28), (5), (1)
Reactivities (31), (10), (7), (2), (2), (2), (2), (1), (1), (1)
Applications (33), (11), (8), (7), (3), (1), (1), (1)
Epitopes (6), (4), (2), (2), (2), (1), (1), (1)
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