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Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2) (Middle Region) antibody

Details for Product No. ABIN183541, Supplier: Login to see New
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Middle Region
(10), (6), (4), (3), (2), (2), (2), (1), (1)
Chicken, Cow (Bovine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Xenopus laevis
(50), (13), (13), (8), (4), (4), (4), (4)
(32), (17), (3)
(1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(49), (29), (7), (7), (4), (4), (2), (1), (1)
Pubmed 1 reference available
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Quantity 100 μg
Shipping to United States ( )
Immunogen Synthetic peptide directed towards the middle region of human CHRNB2
Predicted Reactivity Human : 100 %, Bovine : 90 %, Dog : 90 %, Mouse : 90 %, Pig : 90 %, African clawed frog : 80 %
Characteristics This is a rabbit polyclonal antibody against CHRNB2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name CHRNB2 (CHRNB2 Antibody Abstract)
Background Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.
Molecular Weight 57 kDa
Gene ID 1141
NCBI Accession NP_000739, NM_000748
UniProt P17787
Application Notes Optimal working dilutions should be determined experimentally by the investigator.

Antigen size: 502 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2) (Middle Region) antibody (ABIN183541) WB Suggested Anti-CHRNB2 Antibody Titration: 5.0ug/ml
ELISA Titer: 1...
Background publications Feng, Niu, Xing et al.: "A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men." in: American journal of human genetics, Vol. 75, Issue 1, pp. 112-21, 2004 (PubMed).

Catalog No. ABIN183541

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