TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (C-Term) antibody

Details for Product No. ABIN184155
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Antigen
Synonyms TIAL1, TIAR, zgc:66130, tcbp, tiar, TCBP, 5330433G13Rik, AL033329, mTIAR
Epitope
C-Term
(2), (2), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio), Human, Chicken
(11), (1), (1), (1), (1), (1)
Host
Rabbit
(6), (3), (2)
Clonality
Polyclonal
Application
Western Blotting (WB)
(10), (3), (3), (2), (2), (1)
Pubmed 1 reference available
Quantity 100 µg
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Catalog No. ABIN184155
229.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human TIAL1
Sequence WNQQGFGVDQ SPSAAWMGGF GAQPPQGQAP PPVIPPPNQA GYGMASYQTQ
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Pig : 100 %, Rabbit : 100 %, Mouse : 80 %, Rat : 80 %, Zebrafish : 70 %
Characteristics This is a rabbit polyclonal antibody against TIAL1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name TIAL1
Background The protein encoded by TIAL1 is a member of a family of RNA-binding proteins and possesses nucleolytic activity against cytotoxic lymphocyte target cells. The gene product is a cytotoxic granule-associated protein and has been shown to bind specifically to poly(A) homopolymers and to fragment DNA in permeabilized target cells. It has been suggested that members of this protein family may be involved in the induction of apoptosis. One isoform contains a lysosome-targeting motif in its C-terminal auxiliary domain, however, alternative splicing results in a T-cluster DNA-binding isoform, differing at the C-terminus where a hydrophobic sequence replaces the lysosome-targeting motif.
Molecular Weight 42 kDa
Gene ID 7073
NCBI Accession NM_003252, NP_003243
UniProt Q01085
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 375 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (C-Term) antibody WB Suggested Anti-TIAL1 Antibody Titration: 1.25ug/ml
Positive Control: Jurkat cell lysate
Background publications Esclatine, Taddeo, Roizman: "Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs." in: Journal of virology, Vol. 78, Issue 16, pp. 8582-92, 2004 (PubMed).

Validation Images
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