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Serotonin Receptor 1A antibody (HTR1A) (N-Term)

Details for Product anti-HTR1A Antibody No. ABIN184237, Supplier: Login to see New
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Antigen
Synonyms
5-HT-dro2A, 5-HT1ADro, 5-HT[1A]Dro, 5-HT[[1ADro]], 5-HT[[1A]], 5-HT[[1A]]DRO, 5HT-R2A, 5HT-dro2A, 5HT-drp[[2A]], 5HT1A, 5HT[[1ADro]], 5htdro2a, CG16720, DRO2A, Dm5HTdro2A, Dmel\\CG16720, d5-HT1A, 5htr ... show more
5-HT-dro2A, 5-HT1ADro, 5-HT[1A]Dro, 5-HT[[1ADro]], 5-HT[[1A]], 5-HT[[1A]]DRO, 5HT-R2A, 5HT-dro2A, 5HT-drp[[2A]], 5HT1A, 5HT[[1ADro]], 5htdro2a, CG16720, DRO2A, Dm5HTdro2A, Dmel\\CG16720, d5-HT1A, 5htr1a, htr1a, HTR1A, Htr1a, 5-Ht1a, Gpcr18, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD, RAT5HT1A, 5ht1a, adrb2rl1, adrbrl1, htr1a-A show less
Alternatives
Epitope
N-Term
(10), (9), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(46), (33), (33), (2), (1), (1)
Host
Rabbit
(47), (16), (3)
Clonality
Polyclonal
Conjugate
This Serotonin Receptor 1A antibody is un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(60), (29), (11), (10), (5), (3), (2), (1), (1), (1), (1)
Pubmed 6 references available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human HTR1A
Sequence GQGNNTTSPP APFETGGNTT GISDVTVSYQ VITSLLLGTL IFCAVLGNAC
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against HTR1A. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name HTR1A (HTR1A Antibody Abstract)
Background This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibits adenylate cyclase activity.
Molecular Weight 46 kDa
Gene ID 3350
NCBI Accession NM_000524, NP_000515
UniProt P08908
Pathways JAK-STAT Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 422 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Serotonin Receptor 1A antibody (HTR1A) (N-Term) (ABIN184237) anti-Serotonin Receptor 1A (HTR1A) (N-Term) antibody
Western Blotting (WB) image for anti-Serotonin Receptor 1A antibody (HTR1A) (N-Term) (ABIN184237) Host: Rabbit
Target Name: HTR1A
Sample Tissue: Jurkat Whole Cell lysate...
Western Blotting (WB) image for anti-Serotonin Receptor 1A antibody (HTR1A) (N-Term) (ABIN184237) Host: Rabbit
Target Name: HTR1A
Sample Tissue: Jurkat
Lane A: Pr...
Western Blotting (WB) image for anti-Serotonin Receptor 1A antibody (HTR1A) (N-Term) (ABIN184237) HTR1A Antibody - N-terminal region (AVARP13041_P050) validated by WB using primary cu...
Product cited in: Adeosun, Albert, Austin et al.: "17β-estradiol-induced regulation of the novel 5-HT1A-related transcription factors NUDR and Freud-1 in SH SY5Y cells." in: Cellular and molecular neurobiology, Vol. 32, Issue 4, pp. 517-21, 2012 (PubMed).

Szewczyk, Albert, Rogaeva et al.: "Decreased expression of Freud-1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor, in the prefrontal cortex of subjects with major depression." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 13, Issue 8, pp. 1089-101, 2010 (PubMed).

Iyo, Kieran, Chandran et al.: "Differential regulation of the serotonin 1 A transcriptional modulators five prime repressor element under dual repression-1 and nuclear-deformed epidermal autoregulatory factor by chronic stress." in: Neuroscience, Vol. 163, Issue 4, pp. 1119-27, 2009 (PubMed).

Cordeaux, Pasupathy, Bacon et al.: "Characterization of serotonin receptors in pregnant human myometrium." in: The Journal of pharmacology and experimental therapeutics, Vol. 328, Issue 3, pp. 682-91, 2009 (PubMed).

Szewczyk, Albert, Burns et al.: "Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 12, Issue 2, pp. 155-68, 2009 (PubMed).

Background publications Czesak, Lemonde, Peterson et al.: "Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 6, pp. 1864-71, 2006 (PubMed).

Catalog No. ABIN184237
$289.00
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