JAK-STAT signaling in vertebrates relies on a network of protein kinases and transcription factors to integrate signals from various receptor systems. The multitude of stimuli include cytokines, growth factors, and hormones, binding of which ultimately effect processes such as immune response regulation and cell growth, survival, and differentiation.
The highly conserved pathway involves essentially three levels of processing of the incoming information depending on the function of the respective components:
Besides, negative regulation of these processes takes place on multiple levels:
The prototypical JAK-STAT signaling pathway is rather linear. There is however considerable crosstalk with other signaling cascades like MAPK pathways and JAK independent STAT phosphorylation through receptor tyrosine kinase (RTKs).
JAK1 (Janus Kinase 1): | JAK1 antibodies | JAK1 ELISA Kits | JAK1 Proteins |
JAK2 (Janus Kinase 2): | JAK2 antibodies | JAK2 ELISA Kits | JAK2 Proteins |
TYK2 (Tyrosine Kinase 2): | TYK2 antibodies | TYK2 ELISA Kits | TYK2 Proteins |
JAK3 (Tyrosine-Protein Kinase JAK3): | JAK3 antibodies | JAK3 ELISA Kits | JAK3 Proteins |
STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa): | STAT1 antibodies | STAT1 ELISA Kits | STAT1 Proteins |
STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa): | STAT2 antibodies | STAT2 ELISA Kits | STAT2 Proteins |
STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor)): | STAT3 antibodies | STAT3 ELISA Kits | STAT3 Proteins |
STAT4 (Signal Transducer and Activator of Transcription 4): | STAT4 antibodies | STAT4 ELISA Kits | STAT4 Proteins |
STAT5A (Signal Transducer and Activator of Transcription 5A): | STAT5A antibodies | STAT5A ELISA Kits | STAT5A Proteins |
STAT5B (Signal Transducer and Activator of Transcription 5B): | STAT5B antibodies | STAT5B ELISA Kits | STAT5B Proteins |
STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced): | STAT6 antibodies | STAT6 ELISA Kits | STAT6 Proteins |
SOCS1 (Suppressor of Cytokine Signaling 1): | SOCS1 antibodies | SOCS1 ELISA Kits | SOCS1 Proteins |
SOCS2 (Suppressor of Cytokine Signaling 2): | SOCS2 antibodies | SOCS2 ELISA Kits | SOCS2 Proteins |
CISH (Cytokine Inducible SH2-Containing Protein): | CISH antibodies | CISH Proteins | |
SOCS3 (Suppressor of Cytokine Signaling 3): | SOCS3 antibodies | SOCS3 ELISA Kits | SOCS3 Proteins |
SOCS4 (Suppressor of Cytokine Signaling 4): | SOCS4 antibodies | SOCS4 ELISA Kits | SOCS4 Proteins |
SOCS5 (Suppressor of Cytokine Signaling 5): | SOCS5 antibodies | SOCS5 Proteins | |
SOCS6 (Suppressor of Cytokine Signaling 6): | SOCS6 antibodies | SOCS6 ELISA Kits | SOCS6 Proteins |
PIAS1 (Protein Inhibitor of Activated STAT, 1): | PIAS1 antibodies | PIAS1 ELISA Kits | PIAS1 Proteins |
PIAS3 (Protein Inhibitor of Activated STAT, 3): | PIAS3 antibodies | PIAS3 ELISA Kits | PIAS3 Proteins |
PIAS2 (Protein Inhibitor of Activated STAT, 2): | PIAS2 antibodies | PIAS2 Proteins | |
PIAS4 (Protein Inhibitor of Activated STAT, 4): | PIAS4 antibodies | PIAS4 ELISA Kits | PIAS4 Proteins |
PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11): | PTPN11 antibodies | PTPN11 ELISA Kits | PTPN11 Proteins |
PTPN6 (Protein-tyrosine Phosphatase 1C): | PTPN6 antibodies | PTPN6 ELISA Kits | PTPN6 Proteins |
FYN (FYN Oncogene Related To SRC, FGR, YES): | FYN antibodies | FYN ELISA Kits | FYN Proteins |
SRC (V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian)): | SRC antibodies | SRC ELISA Kits | SRC Proteins |
EPO (Erythropoietin): | EPO antibodies | EPO ELISA Kits | EPO Proteins |
THPO - Thrombopoietin: | THPO antibodies | THPO ELISA Kits | THPO Proteins |
EPOR (Erythropoietin Receptor): | EPOR antibodies | EPOR ELISA Kits | EPOR Proteins |
GH1 - Growth Hormone 1: | GH1 antibodies | GH1 ELISA Kits | GH1 Proteins |
GH2 - Growth Hormone 2: | GH2 antibodies | GH2 ELISA Kits | GH2 Proteins |
GHR - Growth Hormone Receptor: | GHR antibodies | GHR ELISA Kits | GHR Proteins |
MPL (Myeloproliferative Leukemia Virus Oncogene): | MPL antibodies | MPL ELISA Kits | MPL Proteins |
PRL - Prolactin: | PRL antibodies | PRL ELISA Kits | PRL Proteins |
PRLR - Prolactin Receptor: | PRLR antibodies | PRLR ELISA Kits | PRLR Proteins |
CSF2RB (Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity (Granulocyte-Macrophage)): | CSF2RB antibodies | CSF2RB ELISA Kits | CSF2RB Proteins |
CSF2 (Colony Stimulating Factor 2 (Granulocyte-Macrophage)): | CSF2 antibodies | CSF2 ELISA Kits | CSF2 Proteins |
IL-3 (Interleukin 3): | IL-3 antibodies | IL-3 ELISA Kits | IL-3 Proteins |
CSF2RA (Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage)): | CSF2RA antibodies | CSF2RA ELISA Kits | CSF2RA Proteins |
IL3RA (Interleukin 3 Receptor, alpha (Low Affinity)): | IL3RA antibodies | IL3RA ELISA Kits | IL3RA Proteins |
IL5 (Interleukin 5): | IL5 antibodies | IL5 ELISA Kits | IL5 Proteins |
IL5RA (Interleukin 5 Receptor, alpha): | IL5RA antibodies | IL5RA ELISA Kits | IL5RA Proteins |
Ang II - Angiotensin II: | Ang II antibodies | Ang II ELISA Kits | Ang II Proteins |
GNAQ (Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide): | GNAQ antibodies | GNAQ ELISA Kits | GNAQ Proteins |
HTR1A - Serotonin Receptor 1A: | HTR1A antibodies | HTR1A ELISA Kits | HTR1A Proteins |
HTR1B - 5HT1B Receptor: | HTR1B antibodies | HTR1B ELISA Kits | HTR1B Proteins |
HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A): | HTR2A antibodies | HTR2A ELISA Kits | |
HTR7 (5-Hydroxytryptamine (serotonin) Receptor 7 (Adenylate Cyclase-Coupled)): | HTR7 antibodies | HTR7 Proteins | |
AGTR1 - Angiotensin II Type-1 Receptor: | AGTR1 antibodies | AGTR1 ELISA Kits | AGTR1 Proteins |
Ang II/III - Angiotensin II/III: | Ang II/III antibodies | ||
AGT (Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8)): | AGT antibodies | AGT ELISA Kits | AGT Proteins |
HTR1D (Serotonin Receptor 1D): | HTR1D antibodies | HTR1D ELISA Kits | HTR1D Proteins |
HTR1E - Serotonin Receptor 1E: | HTR1E antibodies | HTR1E Proteins | |
HTR1F - 5-Hydroxytryptamine (serotonin) Receptor 1F: | HTR1F antibodies | HTR1F Proteins | |
HTR2B - Serotonin Receptor 2B: | HTR2B antibodies | HTR2B ELISA Kits | HTR2B Proteins |
HTR4 - Serotonin Receptor 4: | HTR4 antibodies | HTR4 ELISA Kits | HTR4 Proteins |
HTR5A - Serotonin Receptor 5A: | HTR5A antibodies | HTR5A Proteins | |
HTR6 - Serotonin Receptor 6: | HTR6 antibodies | HTR6 Proteins |