Retinoid X Receptor, alpha (RXRA) (Internal Region) antibody

Details for Product No. ABIN185295
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Antigen
Synonyms RXRA, 9530071D11Rik, Nr2b1, RXRalpha1, NR2B1, RXRalpha, rxra-A, xRXR alpha, xrxra, RXR alpha, NR2B2-A, RXR, etID309733.19, rxrb, rxre, wu:fb93c09
Epitope
Internal Region
(11), (8), (6), (6), (5), (3), (2), (2), (2), (1), (1)
Reactivity
Human
(53), (13), (13), (3), (2), (2), (2), (2)
Host
Goat
(30), (16), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Methode Type Peptide ELISA
Application
ELISA, Western Blotting (WB)
(51), (25), (8), (7), (3), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 100 µg
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Catalog No. ABIN185295
374.27 $
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Immunogen Peptide with sequence CQVNSSLTSPTGRGSM, from the internal region of the protein sequence according to NP_002948.1.
Specificity This antibody is expected to recognise an epitope corresponding to aa 14-28 of human RXR alpha protein and does not cross-react with either RXR beta or gamma.
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name RXR alpha
Background Synonyms: RXRA, NR2B1, retinoid X receptor, alpha, FLJ16020, FLJ16733, MGC102720, FLJ00280, FLJ00318
Gene ID 6256
NCBI Accession NP_002948
Application Notes ELISA: antibody detection limit dilution 1:16000.
Western blot: Approx 55 kDa band observed in human epidermoid carcinoma A431 lysates (calculated MW of 50.8 kDa according to NP_002948). Recommended concentration: 0.5-3 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
anti-Retinoid X Receptor, alpha (RXRA) (Internal Region) antibody ABIN185295 (0.5µg/ml) staining of A431 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
General Repa, Turley, Lobaccaro et al.: "Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers." in: Science (New York, N.Y.), Vol. 289, Issue 5484, pp. 1524-9, 2000 (PubMed).

Claudel, Leibowitz, Fiévet et al.: "Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 5, pp. 2610-5, 2001 (PubMed).

Germain, Iyer, Zechel et al.: "Co-regulator recruitment and the mechanism of retinoic acid receptor synergy." in: Nature, Vol. 415, Issue 6868, pp. 187-92, 2002 (PubMed).

Validation Images
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