Retinoid X Receptor alpha antibody (N-Term)

Catalog No. ABIN2778244

This Rabbit Polyclonal antibody specifically detects Retinoid X Receptor alpha in WB. It exhibits reactivity toward Human, Rat, Mouse, Guinea Pig, Cow, Dog and Horse.

Quick Overview for Retinoid X Receptor alpha antibody (N-Term) (ABIN2778244)

Target: Retinoid X Receptor alpha (RXRA) (Retinoid X Receptor, alpha (RXRA))

Reactivity: Human, Rat, Mouse, Guinea Pig, Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoid X Receptor alpha antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Retinoid X Receptor alpha Antibody

Binding Specificity: N-Term

Purpose: RXRA Antibody - N-terminal region

Sequence: GPGIGSPGQL HSPISTLSSP INGMGPPFSV ISSPMGPHSM SVPTTPTLGF

Predicted Reactivity: Cow: 100%, Dog: 78%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 78%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against RXRA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RXRA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34060-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Retinoid X Receptor alpha

Target: Retinoid X Receptor alpha (RXRA) (Retinoid X Receptor, alpha (RXRA))

Alternative Name: RXRA

Background:

Background Information: Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. RXRA is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Retinoid X receptor, alpha

Alternative Symbols: NR2B1

Protein Name: Retinoic acid receptor RXR-alpha

Molecular Weight: 51kDa

Gene ID: 6256

NCBI Accession: NP_002948

UniProt: P19793

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Hepatitis C