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Klotho (KL) (Internal Region) antibody

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Synonyms KL, Kitl, LOC100223456, alpha-kl
Internal Region
(28), (7), (7), (7), (6), (5), (5), (3), (3), (2), (2), (1), (1)
(64), (37), (19), (1), (1), (1)
(63), (25), (4)
(8), (6), (3), (3), (3), (3), (1)
Methode Type Peptide ELISA
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(56), (56), (22), (12), (5), (3), (2), (2), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 100 μg
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Immunogen Peptide with sequence C-KRDDAKYMYYLKK, from the internal region of the protein sequence according to NP_004786.2, NP_710150.1.
Blocking Peptide Blocking peptide for this product available: ABIN369353
Specificity This antibody is expected to recognise both reported isoforms (NP_004786.2, NP_710150.1).
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name Klotho (KL Antibody Abstract)
Background Synonyms: KL, klotho
Gene ID 9365
NCBI Accession NP_710150, NP_004786
Research Area Metabolism
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes ELISA: antibody detection limit dilution 1:4000.
Western blot: Preliminary experiments in human brain, duodenum, placenta and prostate lysates gave no specific signal but low background (at antibody concentration up to 1 µg/mL).
IHC: In paraffin embedded Human Breast shows cytoplasm staining in luminal epithelial cells of ducts, while Human Placenta shows membranous staining. Recommended concentration: 4-6 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Background publications Kurosu, Yamamoto, Clark et al.: "Suppression of aging in mice by the hormone Klotho." in: Science (New York, N.Y.), Vol. 309, Issue 5742, pp. 1829-33, 2005 (PubMed).

Catalog No. ABIN185513
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