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Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (C-Term) antibody

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Synonyms TREM-A1, TREM-B1, TREM2, trem-2, trem2a, trem2b, trem2c, TREM-2, Trem2a, Trem2b, Trem2c
(31), (17), (16), (14), (10), (8), (7), (6), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(81), (71), (18)
(62), (35), (28), (10), (1)
(11), (11), (7), (7), (7), (6), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Methode Type Peptide ELISA
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(73), (69), (25), (15), (11), (10), (4), (4), (3), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 100 μg
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Immunogen Peptide with sequence C-HGQKPGTHPPSELD, from the C Terminus of the protein sequence according to NP_061838.1.
Blocking Peptide Blocking peptide for this product available: ABIN369160
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name TREM2 (TREM2 Antibody Abstract)
Background Synonyms: TREM2, triggering receptor expressed on myeloid cells 2, TREM-2, Trem2a, Trem2b, Trem2c, OTTHUMP00000039771, triggering receptor expressed on myeloid cells 2a
Gene ID 54209
NCBI Accession NP_061838
Research Area Immunology, Innate Immunity, Signaling
Application Notes ELISA: antibody detection limit dilution 1:32000.
Western blot: Preliminary experiments gave bands at approx 80 kDa and 30 kDa in Human Brain (Cerebellum) lysates after 1 µg/mL antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 25.4 kDa according to NP_061838.1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
IHC: In paraffin embedded Human Spleen shows staining of macrophages. Recommended concentration: 2-3 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Background publications Takahashi, Prinz, Stagi et al.: "TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis." in: PLoS medicine, Vol. 4, Issue 4, pp. e124, 2007 (PubMed).

Catalog No. ABIN190752
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