Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (C-Term) antibody

Details for Product No. ABIN190752
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Antigen
Synonyms TREM-2, Trem2a, Trem2b, Trem2c, TREM-A1, TREM-B1, TREM2, trem-2, trem2a, trem2b, trem2c
Epitope
C-Term
(5), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(43), (36), (13), (12), (12), (12)
Host
Goat
(23), (16), (11), (10), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Methode Type Peptide ELISA
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(34), (28), (12), (10), (7), (6), (4), (2), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN190752
Quantity 100 µg
Price
374.27 $   Plus shipping costs $45.00
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Immunogen Peptide with sequence C-HGQKPGTHPPSELD, from the C Terminus of the protein sequence according to NP_061838.1.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name TREM2
Background Synonyms: TREM2, triggering receptor expressed on myeloid cells 2, TREM-2, Trem2a, Trem2b, Trem2c, OTTHUMP00000039771, triggering receptor expressed on myeloid cells 2a
Gene ID 54209
NCBI Accession NP_061838.1
Research Area Immunology, Innate Immunity, Signaling
Application Notes ELISA: antibody detection limit dilution 1:32000.
Western blot: Preliminary experiments gave bands at approx 80 kDa and 30 kDa in Human Brain (Cerebellum) lysates after 1 µg/mL antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 25.4 kDa according to NP_061838.1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
IHC: In paraffin embedded Human Spleen shows staining of macrophages. Recommended concentration: 2-3 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
General Takahashi, Prinz, Stagi et al.: "TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis." in: PLoS medicine, Vol. 4, Issue 4, pp. e124, 2007 (PubMed).

Hosts (23), (16), (11), (10), (1)
Reactivities (43), (36), (13), (12), (12), (12)
Applications (34), (28), (12), (10), (7), (6), (4), (2), (1), (1)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1)
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