Dyskeratosis Congenita 1, Dyskerin (DKC1) (Internal Region) antibody

Details for Product No. ABIN190831
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Antigen
Synonyms
CBF5, DKC, DKCX, NAP57, NOLA4, XAP101, dyskerin, BC068171, Nap57, AtCBF5, AtNAP57, homologue of NAP57, fv62a07, wu:fa28f10, wu:fc87a02, wu:fi24a05, wu:fv62a07, zgc:110395, DKC1, cbf5, dkc, nap57, nola ... show more
CBF5, DKC, DKCX, NAP57, NOLA4, XAP101, dyskerin, BC068171, Nap57, AtCBF5, AtNAP57, homologue of NAP57, fv62a07, wu:fa28f10, wu:fc87a02, wu:fi24a05, wu:fv62a07, zgc:110395, DKC1, cbf5, dkc, nap57, nola4, xap101 show less
Epitope
Internal Region
(6), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(40), (32), (27), (13), (13), (13), (13), (1)
Host
Goat
(35), (6), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Methode Type Peptide ELISA
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(27), (16), (14), (10), (10), (7), (6), (1)
Pubmed 1 reference available
Catalog no. ABIN190831
Quantity 100 µg
Price
374.27 $   Plus shipping costs $45.00
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Immunogen Peptide with sequence C-KRKRESESESDETPP, from the internal region of the protein sequence according to NP_001354.1.
Cross-Reactivity Mouse (Murine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name DKC1
Background Synonyms: DKC1, dyskeratosis congenita 1, dyskerin, DKC, NAP57, NOLA4, XAP101
Gene ID 1736, 245474
NCBI Accession NP_001354.1
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins, DNA/RNA
Application Notes ELISA: antibody detection limit dilution 1:128000.
Western blot: Preliminary experiments gave an approx 70-75 kDa band in Human Bone Marrow, Duodenum and Skin lysates after 0.01 µg/mL antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 57.7 kDa according to NP_001354.1. The 70-75 kDa band was successfully blocked by incubation with the immunizing peptide.
IHC: In paraffin embedded Human Spleen shows strong nuclear staining of select splenocytes. Recommended concentration: 5-10 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) (Internal Region) antibody ABIN190831 (5µg/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
General Yoon, Peng, Brandenburger et al.: "Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita." in: Science (New York, N.Y.), Vol. 312, Issue 5775, pp. 902-6, 2006 (PubMed).

Hosts (35), (6), (1)
Reactivities (40), (32), (27), (13), (13), (13), (13), (1)
Applications (27), (16), (14), (10), (10), (7), (6), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (2), (2), (1), (1), (1), (1), (1)
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