DKC1 antibody (AA 94-170)

Catalog No. ABIN7154810

Product Details anti-DKC1 Antibody

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Binding Specificity: AA 94-170

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human H/ACA ribonucleoprotein complex subunit 4 protein (94-170AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DKC1

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Alternative Name: DKC1 (DKC1 Products)

Synonyms: CBF5 antibody, DKC antibody, DKCX antibody, NAP57 antibody, NOLA4 antibody, XAP101 antibody, dyskerin antibody, fv62a07 antibody, wu:fa28f10 antibody, wu:fc87a02 antibody, wu:fi24a05 antibody, wu:fv62a07 antibody, zgc:110395 antibody, DKC1 antibody, cbf5 antibody, dkc antibody, nap57 antibody, nola4 antibody, xap101 antibody, BC068171 antibody, Nap57 antibody, AtCBF5 antibody, AtNAP57 antibody, homologue of NAP57 antibody, dyskerin pseudouridine synthase 1 antibody, microRNA 664b antibody, dyskeratosis congenita 1, dyskerin antibody, dyskeratosis congenita 1, dyskerin L homeolog antibody, homologue of NAP57 antibody, DKC1 antibody, MIR664B antibody, dkc1 antibody, dkc1.L antibody, Dkc1 antibody, NAP57 antibody

Background:

Background: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (\\\'psi\\\') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

Aliases: CBF5 antibody, CBF5 homolog antibody, Cbf5p homolog antibody, DKC 1 antibody, DKC antibody, Dkc1 antibody, DKC1_HUMAN antibody, DKCX antibody, Dyskeratosis congenita 1 antibody, Dyskeratosis congenita 1 dyskerin antibody, Dyskerin antibody, H/ACA ribonucleoprotein complex subunit 4 antibody, NAP 57 antibody, NAP57 antibody, NOLA 4 antibody, NOLA4 antibody, Nopp140 associated protein of 57 kDa antibody, Nopp140-associated protein of 57 kDa antibody, Nucleolar protein family A member 4 antibody, Nucleolar protein NAP57 antibody, snoRNP protein DKC1 antibody, XAP 101 antibody, XAP101 antibody

UniProt: O60832

Pathways: Telomere Maintenance