TNFRSF10A antibody

Catalog No. ABIN1959968

Product Details anti-TNFRSF10A Antibody

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF10A antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Functional Studies (Func), Blocking Reagent (BR), Neutralization (Neut)

Specificity: Monoclonal antibody DR-4-02 recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumor-derived cell lines.

Purification: Protein A purified

Immunogen: Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.

Type of Immunogen: Fusion protein

Clone: DR-4-02

Isotype: IgG1

Application Details

Application Notes: Approved: Block, Flo, Func, ICC, IP, Neut

Usage: Flow Cytometry: Recommended dilution - 3-5 μg/mL. Functional Application: Soluble antibody DR-4-02 blocks apoptosis triggered by a ligand (TRAIL). Plastic-immobilized (cross-linked) DR-4-02 antibody induces apoptosis in sensitive cells. Recommended diluti

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 15 mM sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for TNFRSF10A

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Alternative Name: TNFRSF10A / DR4 (TNFRSF10A Products)

Background: Name/Gene ID: TNFRSF10A
Family: TNF Receptor

Synonyms: TNFRSF10A, APO2, CD261, DR4, TRAIL-R1, TRAILR-1, TRAILR1, TRAIL receptor 1, CD261 antigen, Cytotoxic TRAIL receptor, Death receptor 4

Gene ID: 8797

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity