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Details for Product No. ABIN233753

Mesothelin (MSLN) (Extracellular Domain) antibody

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Synonyms MPF, SMRP, MSLN
»Alternatives Extracellular Domain
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN233753
Quantity 100 µg
361.90 $   Plus shipping costs $45.00 and if applicable $26.40 dry ice
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Immunogen This antibody was produced in mice by repeated immunizations with a recombinant protein corresponding to the of human mesothelin.
Clone MN-1
Isotype IgG
Characteristics Concentration Definition: by UV absorbance at 280 nm
Alternative Name Mesothelin
Background Anti Mesothelin Antibody recognizes Mesothelin that is a glycosyl-phosphatidylinositol–anchored glycoprotein present on the cell surface of various human solid tumors.  The mesothelin (MSLN) gene encodes a 71-kDa precursor protein that is processed to a 40-kDa glycosylphosphatidylinositol–anchored protein that composes the mature portion and an NH2 terminal 31-kDa fragment called megakaryocyte-potentiating factor that is released from the cell.  Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues, such as mesothelium, but aberrantly over expressed in mesotheliomas, ovarian, and pancreatic cancers.  The biological functions of mesothelin remain elusive.  A recent study showed that mesothelin binds to MUC16/CA125, and that this interaction mediates cell adhesion, suggesting that there may be an important role for MUC16/CA125 and mesothelin in the metastatic spread of ovarian cancer.
Synonyms: Mesothelian, MN, MB, Pre-pro-megakaryocyte-potentiating factor, CAK1 antigen
Gene ID 10232
NCBI Accession NP_005814
UniProt Q13421
Research Area Cancer
Application Notes This antibody has been tested for use in immunohistochemistry and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 40 kDa in size corresponding to mature mesothelin by western blotting in the appropriate cell lysate or extract. For immunohistochemistry, archival PEFF human tissues were deparaffinized followed by hydration.  Antigen-retrieval is recommended.  Block tissues with 1% BSA in PBS for 30 min at 23° C.  Antibodies are diluted in 1% BSA and reacted with tissue for 60 min at room temperature.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Storage -20 °C
Xiang, Phung, Feng et al.: "The Development and Characterization of a Human Mesothelioma In Vitro 3D Model to Investigate Immunotoxin Therapy." in: PLoS ONE, Vol. 6, Issue 1, pp. e14640, 2011 (PubMed).

Alternatives for antigen "Mesothelin (MSLN)", type "Antibodies"
Hosts (50), (34), (7), (3)
Reactivities (81), (8), (5), (3), (1), (1)
Applications (46), (40), (25), (11), (10), (9), (6), (5), (4), (4), (4), (3), (3), (2), (1)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (7), (5), (2), (2), (2), (2), (2), (1), (1)