CYP2B6 antibody

Catalog No. ABIN2718982

Product Details anti-CYP2B6 Antibody

Target: CYP2B6 (Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))

Reactivity: Human, Mouse, Rat, Dog, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This CYP2B6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Characteristics: Homo sapiens cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6)

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human CYP2B6(NP_000758) produced in HEK293T cell.

Clone: 3D5

Isotype: IgG2a

Application Details

Application Notes: WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-CYP2B6 antibody (ABIN2718982)

Sim, Nam, Lee, Lee, O, Joo, Liu, Han, Ki, Jeong, Lee, Lee: "Selective induction of hepatic cytochrome P450 2B activity by leelamine in vivo, as a potent novel inducer." in: Archives of pharmacal research, Vol. 38, Issue 5, pp. 725-33, (2015) (PubMed).

Chai, Feng, Zhang, Chen, Cheng, He, Yang, He, Wang, Wang, Chen: "Hepatic expression of detoxification enzymes is decreased in human obstructive cholestasis due to gallstone biliary obstruction." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120055, (2015) (PubMed).

Fredman, Li, Dalli, Chiang, Serhan: "Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA." in: Scientific reports, Vol. 2, pp. 639, (2012) (PubMed).

Target Details for CYP2B6

Target: CYP2B6 (Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))

Alternative Name: CYP2B6 (CYP2B6 Products)

Background: This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described, however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

Molecular Weight: 56.1 kDa

Gene ID: 1555

NCBI Accession: NM_000767

HGNC: 1555