DOK7 antibody

Catalog No. ABIN2719658

Product Details anti-DOK7 Antibody

Target: DOK7 (Docking Protein 7 (DOK7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DOK7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Characteristics: Homo sapiens docking protein 7 (DOK7), transcript variant 1

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human DOK7(NP_775931) produced in HEK293T cell.

Clone: 1F7

Isotype: IgG1

Application Details

Application Notes: WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for DOK7

Target: DOK7 (Docking Protein 7 (DOK7))

Alternative Name: DOK7 (DOK7 Products)

Background: The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.

Molecular Weight: 52.9 kDa

Gene ID: 285489

NCBI Accession: NM_173660

HGNC: 285489

Pathways: Skeletal Muscle Fiber Development