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CD3 epsilon antibody (Biotin)

CD3E Reactivity: Mouse FACS Host: Hamster Monoclonal 145-2C11 Biotin

Catalog No. ABIN2567601

Datasheet as PDF

Target See all CD3 epsilon (CD3E) Antibodies

CD3 epsilon (CD3E)
Reactivity
229

159

51

42

18

8

8

8

7

4

4

4

4

3

3

3

3

3

3

1

1
Mouse
Host
133

126

37

23

20

8

1

1

1
Hamster
Clonality
232

112

6
Monoclonal
Conjugate
137

31

27

22

17

8

8

5

5

4

4

4

4

4

4

4

4

4

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1
This CD3 epsilon antibody is conjugated to Biotin
Application
254

142

103

78

74

73

27

24

23

22

14

13

13

13

8

6

5

3

3

1

1

1

1

1

1

1

1

1
Flow Cytometry (FACS)

Specificity

The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa ε chain of the TCR complex.

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Clone

145-2C11

Isotype

IgG

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CD3E Reactivity: Human WB, IHC, IP Host: Rabbit Polyclonal unconjugated

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CD3E Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated

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CD3E Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-CD3 epsilon (CD3E) (AA 23-207) antibody
CD3E Reactivity: Human WB, IHC, IF, ELISA Host: Rabbit Polyclonal unconjugated

Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Liquid

Concentration

0.5 mg/mL

Buffer

Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Storage

4 °C

Storage Comment

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Target

CD3 epsilon (CD3E)

Alternative Name

CD3e (CD3E Products)

Background

The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa ε chain of the TCR complex. Together with the γ and δ subunits of CD3, the ε subunits are involved in the assembly, trafficking, and surface expression of T-cell receptor complex. CD3 is expressed on thymocytes, mature T cells, and natural killer T cells, and the ε chain enhances the antigen recognition.The 145-2C11 antibody binds to the TCR complex and, depending on the conditions, initiates T cells activation, proliferation, and apoptosis. The soluble antibody seems to block lysis of target cells by antigen-specific cytotoxic T lymphocytes. The 145-2C11 antibody does not cross-react with the rat leukocytes, and it is used as a phenotypic marker for mouse T lymphocytes.

Gene ID

12501

UniProt

P22646

Pathways

TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway