Alanyl (Membrane) Aminopeptidase (ANPEP) antibody (Biotin)

Details for Product No. ABIN263532
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Antigen
Synonyms Apn, pepN, SC8E4A.13, APN, CD13, GP150, LAP1, P150, PEPN, AP-M, AP-N, Cd13, Apm, KZP, Lap1, rAPN, APDE, p150
Reactivity
Human
(193), (60), (7), (7), (6), (6), (3), (1)
Host
Mouse
(158), (50), (49), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
(40), (30), (15), (11), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
(186), (58), (45), (45), (42), (39), (25), (14), (5), (4), (3), (3), (1), (1)
Pubmed 1 reference available
Quantity 0.2 mg
Shipping to United States (Change)
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Catalog No. ABIN263532
533.50 $
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Immunogen A cell suspension containing osteoclasts from osteoclastomas
Clone 22A5
Isotype IgG
Characteristics Synonyms: Aminopeptidase N, ANPEP, APN, PEPN, Alanyl aminopeptidase, Microsomalaminopeptidase, Aminopeptidase M, gp150, Myeloid plasma membrane glycoprotein CD13
Purification Protein G Chromatography.
Alternative Name CD13
Background CD13 also known as Aminopeptidase N is a zinc dependent exopeptidase which cleavesamino acids from the N-termini of target proteins including neuropeptides and cytokines. CD13 is expressed on all cells of the myeloid lineage as well as epithelial cells of theintestine, placenta, liver and kidney. CD13 is upregulated in a number of tumour typesincluding lung, melanoma, thyroid and hepatocarcinoma and has been shown to correlatewith poor prognosis. CD13 is a crucial molecule in tumour angiogenesis. CD13 is also thereceptor for viruses from the coronavirus family.
UniProt P15144
Research Area Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells, Extracellular Matrix, Signaling
Application Notes Suitable for use in Flow Cytometry and Immunohistochemistry (acetone-fixed frozensections). We recommend using 1 µg to stain 1.0 x 10e6 cells in Flow Cytometric applications. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL (OD280nm)
Buffer 0.01M PBS, pH 7.2 containing 2mM EDTA, 1% BSA as stabilizer and 0.09% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Horton, Lewis, McNulty et al.: "Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens." in: Cancer research, Vol. 45, Issue 11 Pt 2, pp. 5663-9, 1985 (PubMed).

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