CD13 antibody (Biotin)

Catalog No. ABIN263532

Product Details anti-CD13 Antibody (Biotin)

Target: CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD13 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: This antibody recognizes the (Mr 150-170 kDa) cell surface glycoprotein expressed in a pan-myeloid fashion. This antibody also reacts with osteoclasts in giant cell tumors of bone (osteoclastoma), clear cell chondrosarcoma and aneurysmal bone cysts.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: Aminopeptidase N, ANPEP, APN, PEPN, Alanyl aminopeptidase, Microsomalaminopeptidase, Aminopeptidase M, gp150, Myeloid plasma membrane glycoprotein CD13

Purification: Protein G Chromatography.

Immunogen: A cell suspension containing osteoclasts from osteoclastomas

Clone: 22A5

Isotype: IgG

Application Details

Application Notes: Suitable for use in Flow Cytometry and Immunohistochemistry (acetone-fixed frozensections). We recommend using 1 μg to stain 1.0 x 10^6 cells in Flow Cytometric applications.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL (OD280nm)

Buffer: 0.01 M PBS, pH 7.2 containing 2 mM EDTA, 1 % BSA as stabilizer and 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD13

Target: CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))

Alternative Name: CD13 (ANPEP Products)

Synonyms: APN antibody, CD13 antibody, GP150 antibody, LAP1 antibody, P150 antibody, PEPN antibody, A2AP antibody, AAP antibody, ALPHA-2-PI antibody, API antibody, PLI antibody, AAT1 antibody, ALT1 antibody, GPT1 antibody, Gpt1 antibody, Apn antibody, pepN antibody, SC8E4A.13 antibody, 1300007J06Rik antibody, 2310022B03Rik antibody, ALT antibody, Gpt-1 antibody, AP-M antibody, AP-N antibody, Cd13 antibody, Apm antibody, KZP antibody, Lap1 antibody, rAPN antibody, APDE antibody, p150 antibody, anpep antibody, fb64c05 antibody, wu:fb64c05 antibody, zgc:136771 antibody, alanyl aminopeptidase, membrane antibody, serpin family F member 2 antibody, glutamic--pyruvic transaminase antibody, aminopeptidase N antibody, aminopeptidase antibody, aminopeptidase n antibody, glutamic pyruvic transaminase, soluble antibody, alanyl (membrane) aminopeptidase antibody, membrane alanyl aminopeptidase antibody, alanyl (membrane) aminopeptidase b antibody, alanyl aminopeptidase, membrane L homeolog antibody, ANPEP antibody, SERPINF2 antibody, GPT antibody, Gpt antibody, Apn2 antibody, Apn1 antibody, SCO2643 antibody, pepN antibody, Shewana3_0897 antibody, Alvin_1024 antibody, Ndas_3413 antibody, Saut_1544 antibody, Fbal_1877 antibody, ML5_3424 antibody, Despr_1988 antibody, Mesop_5365 antibody, Anpep antibody, LOC101744250 antibody, anpepb antibody, anpep.L antibody

Background: CD13 also known as Aminopeptidase N is a zinc dependent exopeptidase which cleaves amino acids from the N-termini of target proteins including neuropeptides and cytokines. CD13 is expressed on all cells of the myeloid lineage as well as epithelial cells of the intestine, placenta, liver and kidney. CD13 is upregulated in a number of tumour types including lung, melanoma, thyroid and hepatocarcinoma and has been shown to correlate with poor prognosis. CD13 is a crucial molecule in tumour angiogenesis. CD13 is also the receptor for viruses from the coronavirus family.Synonyms: ANPEP, APN, Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, PEPN, gp150

Gene ID: 290

UniProt: P15144

Pathways: Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones