Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) antibody

Details for Product No. ABIN264405
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Antigen
Synonyms xCaspase-6, mch2, caspase-6, zgc:112960, CASP6, casp6, Mch2, mCASP-6, MCH2
Reactivity
Human
(217), (102), (86), (13), (6), (2), (1)
Host
Mouse
(210), (26), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(11), (10), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB)
(200), (108), (81), (55), (40), (32), (30), (14), (8), (5), (5), (4), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN264405
324.50 $
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Immunogen Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman capase-6 protein and mouse myeloma cells. Genename: CASP6
Clone MCH2 14 1-190
Isotype IgG1
Specificity Detects proenzyme form of human Caspase-6 by Western blot.
Characteristics Synonyms: CASP-6, CASP6, MCH2, MCH-2, Apoptotic protease Mch-2
Purification Purified
Alternative Name Caspase-6
Background Caspase-6 (Cysteine-Requiring Aspartate Proteases) is part of a family of intracellular cysteine proteases that cleave their substrates after aspartic acid residues. These proteases play an integral role in inducing apoptosis in cells. Procaspase-6 (Mch2), a member of the ICE/ced-3 subfamily, is an inactive proenzyme that is activated to form caspase-6 by proteolytic cleavage at certain aspartic acid residues. During cleavage, the N-terminal is removed and the proenzyme is converted into a large (p18) and small (p11) subunits. Caspase-6 has two isoforms produced by alternative splicing. Over-expression of the isoform of caspase-6 without its prodomain can induce apoptosis. The isoform does not seem to display proteolytic activity. Together with caspases-3 and -7, the isoform of caspase-6 is classified as an effector/execution caspase. Caspase-3, caspase-8 and caspase-10 can cleave procaspase-6. Active caspase-6 cleaves several other proteins such as lamins, NuMa and Keratin 18. A possible cleavage of caspases-8 and -10 in cytochrome-C dependent apoptosis was reported recently.Synonyms: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2
Gene ID 839
UniProt P55212
Research Area Apoptosis/Necrosis
Application Notes Western Blot. Positive Control: MCF-7 cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.08 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch
Expiry Date 12 months
Supplier Images
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) antibody anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) antibody
Background publications Fernandes-Alnemri, Litwack, Alnemri: "Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family." in: Cancer research, Vol. 55, Issue 13, pp. 2737-42, 1995 (PubMed).

Orth, Chinnaiyan, Garg et al.: "The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A." in: The Journal of biological chemistry, Vol. 271, Issue 28, pp. 16443-6, 1996 (PubMed).

Hirata, Takahashi, Kobayashi et al.: "Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis." in: The Journal of experimental medicine, Vol. 187, Issue 4, pp. 587-600, 1998 (PubMed).

Kidd: "Proteolytic activities that mediate apoptosis." in: Annual review of physiology, Vol. 60, pp. 533-73, 1998 (PubMed).

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