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Details for Product No. ABIN264405

Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) antibody

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Antigen
Synonyms MCH2, Mch2, mCASP-6, xCaspase-6, mch2, caspase-6, zgc:112960, CASP6, casp6
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN264405
Quantity 0.1 mg
Price
313.50 $   Plus shipping costs $45.00
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Immunogen Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman capase-6 protein and mouse myeloma cells. Genename: CASP6
Clone MCH2 14 1-190
Isotype IgG1
Characteristics Synonyms: CASP-6, CASP6, MCH2, MCH-2, Apoptotic protease Mch-2
Purification Purified
Alternative Name Caspase-6
Background Caspase-6 (Cysteine-Requiring Aspartate Proteases) is part of a family of intracellularcysteine proteases that cleave their substrates after aspartic acid residues. Theseproteases play an integral role in inducing apoptosis in cells. Procaspase-6 (Mch2), amember of the ICE/ced-3 subfamily, is an inactive proenzyme that is activated to formcaspase-6 by proteolytic cleavage at certain aspartic acid residues. During cleavage, theN-terminal is removed and the proenzyme is converted into a large (p18) and small (p11)subunits. Caspase-6 has two isoforms produced by alternative splicing. Over-expression ofthe isoform of caspase-6 without its prodomain can induce apoptosis. The isoform doesnot seem to display proteolytic activity. Together with caspases-3 and -7, the isoform ofcaspase-6 is classified as an effector/execution caspase. Caspase-3, caspase-8 andcaspase-10 can cleave procaspase-6. Active caspase-6 cleaves several other proteins suchas lamins, NuMa and Keratin 18. A possible cleavage of caspases-8 and -10 incytochrome-C dependent apoptosis was reported recently.
UniProt P55212
Research Area Apoptosis/Necrosis
Application Notes Western Blot. Positive Control: MCF-7 cell lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.08% Sodium Azide as preservative.
Preservative Sodium azide
Storage -20 °C
Storage Comment Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch
Expiry Date 12 months
Background publications Fernandes-Alnemri, Litwack, Alnemri: "Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family." in: Cancer research, Vol. 55, Issue 13, pp. 2737-42, 1995 (PubMed).

Orth, Chinnaiyan, Garg et al.: "The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A." in: The Journal of biological chemistry, Vol. 271, Issue 28, pp. 16443-6, 1996 (PubMed).

Hirata, Takahashi, Kobayashi et al.: "Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis." in: The Journal of experimental medicine, Vol. 187, Issue 4, pp. 587-600, 1998 (PubMed).

Kidd: "Proteolytic activities that mediate apoptosis." in: Annual review of physiology, Vol. 60, pp. 533-73, 1998 (PubMed).

Alternatives for antigen "Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6)", type "Antibodies"
Hosts (160), (32), (2)
Reactivities (181), (94), (83), (16), (7), (4), (2), (2), (2), (2), (2)
Applications (149), (72), (63), (40), (40), (29), (25), (20), (7), (5), (4), (2), (2), (1), (1), (1)
Conjugates (8), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (43), (29), (22), (8), (7), (6), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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