Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7) antibody

Details for Product No. ABIN264406
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Antigen
Synonyms xCaspase-7, caspase-7, caspase7, cmh-1, ice-lap3, mch3, CASP7, AI314680, CMH-1, ICE-IAP3, Mch3, mCASP-7, CASP-7, ICE-LAP3, LICE2, MCH3, Caspase-7, MCH3/SCA-2, SCA-2
Reactivity
Human
(180), (85), (64), (26), (24), (13), (12), (3), (3), (2), (1), (1), (1)
Host
Mouse
(150), (36), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(161), (73), (54), (48), (23), (20), (12), (9), (8), (3), (2)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN264406
324.50 $
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Immunogen Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman capase-7 protein and mouse myeloma cells. Genename: CASP7
Clone MCH3 14 1-11
Isotype IgG1
Characteristics Synonyms: CASP-7, CASP7, MCH3, CMH-1, ICE-like apoptotic protease 3, Apoptotic protease Mch-3
Purification Purified
Alternative Name Caspase-7
Background Caspases are key effectors of programmed cell death. Caspase-7 along with caspase 3 and6 form the group of effector caspases that are responsible for the cleavage of multiplesubstrates including the cytokeratins, PARP, alpha fodrin, NuMA and others. Caspase-7 isa 303 amino acid protein with high similarity to caspase-3. Caspase-7 occurs in threevarient forms. Granzyme B activates pro-caspase-7 to a form which can cleavepoly(ADP-ribose) polymerase (PARP) to its signature fragment of ~85 kDa. Also, in vivocaspase-7 appears to be a better substrate for granzyme B than caspase-3. Pro-caspase-7has been shown to exist as dimers or high order oligomers. Caspase-7 may be animportant intracellular effector of granzyme B-mediated apoptosis and cytotoxicT-lymophocyte-induced cell killing in vivo.
UniProt P55210
Research Area Apoptosis/Necrosis
Application Notes Western Blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.08% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Expiry Date 12 months
Background publications Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Behrensdorf, van de Craen, Knies et al.: "The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7." in: FEBS letters, Vol. 466, Issue 1, pp. 143-7, 2000 (PubMed).

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