Keratin 14 (KRT14) antibody

Details for Product No. ABIN264414
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Synonyms Krt14, KRT14, CK14, ouro2, EBS3, EBS4, K14, NFJ, AI626930, Krt-1.14, Krt1-14, Ka14
(165), (26), (23), (7), (5), (3), (2)
(87), (75), (5)
Clonality (Clone)
Monoclonal ()
(5), (3)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(112), (76), (58), (43), (34), (34), (22), (15), (10), (6), (3), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN264414
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Immunogen Synthetic peptide conjugated to KLH corresponding to thecarboxy terminal sequence of human cytokeratin 14(KVVSTHEQVLRTKN)Genename: KRT14
Clone DE-SPK14
Isotype IgG2b
Specificity This antibody reacts specifically with Human Cytokeratin-14 (50 kDa) by Immunoblotting. Does not react with other Cytokeratins or other proteins.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Characteristics Synonyms: Cytokeratin-14, CK14, Keratin 14, K14, KRT14, Keratin Type I Cytoskeletal 14
Purification Protein A/G Chromatography
Alternative Name Cytokeratin 14
Background Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non-keratinizing cells (ie., mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Keratin 14 is a member of the keratin family, the most diverse group of intermediate filaments. It is usually found as a heterotetramer with two molecules of keratin 5, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. Keratin 14 has been studied as a prognostic marker in breast cancer.Synonyms: CK14, Cytokeratin-14, K14, KRT14, Keratin 14, Keratin Type I Cytoskeletal 14
Gene ID 3861
UniProt P02533
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix, Cancer
Application Notes Western Blot: Detects human cytokeratin 14 at 50 kDa. Immunohistochemistry (Frozen Sections): It provides a positive reaction on basal cells ofnon-keratinizing stratified epithelia, basal cells and suprabasal cells of the epidermis andgingiva, myoepithelial cells and squamous cell carcinomas. Not suitable for use in Paraffin embedded tissues.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS, 0.08 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Expiry Date 12 months
Background publications Moll, Franke, Schiller et al.: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).

Ivanyi, Minke, Hageman et al.: "Patterns of expression of feline cytokeratins in healthy epithelia and mammary carcinoma cells." in: American journal of veterinary research, Vol. 53, Issue 3, pp. 304-14, 1992 (PubMed).

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