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Keratin 14 (KRT14) antibody

Details for Product No. ABIN264414
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Antigen
Synonyms Krt14, KRT14, CK14, ouro2, EBS3, EBS4, K14, NFJ, AI626930, Krt-1.14, Krt1-14, Ka14
Reactivity
Human
(130), (26), (22), (7), (4), (3), (2)
Host
Mouse
(71), (57), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(83), (75), (45), (31), (26), (21), (16), (16), (2), (2)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN264414
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Immunogen Synthetic peptide conjugated to KLH corresponding to thecarboxy terminal sequence of human cytokeratin 14(KVVSTHEQVLRTKN)Genename: KRT14
Clone DE-SPK14
Isotype IgG2b
Characteristics Synonyms: Cytokeratin-14, CK14, Keratin 14, K14, KRT14, Keratin Type I Cytoskeletal 14
Purification Protein A/G Chromatography
Alternative Name Cytokeratin 14
Background Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue(ie. , skin) and non-keratinizing cells (ie. , mesothelial cells). Although not a traditionalmarker for endothelial cells, cytokeratins have also been found in some microvascularendothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDaand isoelectric points of 5-8. 5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidicpolypeptides) and type II (basic polypeptides). At least one member of the acidic familyand one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumoridentification and classification.
UniProt P02533
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix, Cancer
Application Notes Western Blot: Detects human cytokeratin 14 at 50 kDa. Immunohistochemistry (Frozen Sections): It provides a positive reaction on basal cells ofnon-keratinizing stratified epithelia, basal cells and suprabasal cells of the epidermis andgingiva, myoepithelial cells and squamous cell carcinomas. Not suitable for use in Paraffin embedded tissues. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS 0.08% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Expiry Date 12 months
Background publications Ivanyi, Minke, Hageman et al.: "Patterns of expression of feline cytokeratins in healthy epithelia and mammary carcinoma cells." in: American journal of veterinary research, Vol. 53, Issue 3, pp. 304-14, 1992 (PubMed).

Moll, Franke, Schiller et al.: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).

Validation Images
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