Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7) antibody

Details for Product No. ABIN264418
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Antigen
Synonyms xCaspase-7, caspase-7, caspase7, cmh-1, ice-lap3, mch3, CASP7, AI314680, CMH-1, ICE-IAP3, Mch3, mCASP-7, CASP-7, ICE-LAP3, LICE2, MCH3, Caspase-7, MCH3/SCA-2, SCA-2
Reactivity
Human
(180), (85), (64), (26), (24), (13), (12), (3), (3), (2), (1), (1), (1)
Host
Mouse
(150), (36), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(161), (73), (54), (48), (23), (20), (12), (9), (8), (3), (2)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN264418
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Immunogen Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman caspase-7 protein and mouse myeloma cells. Genename: CASP7
Clone MCH3-5
Isotype IgG
Characteristics Synonyms: CASP-7, CASP7, MCH3, CMH-1, ICE-like apoptotic protease 3, Apoptotic protease Mch-3
Purification Purified
Alternative Name Caspase-7
Background Caspases are key effectors of programmed cell death. Caspase-7 along with caspase 3 and6 form the group of effector caspases that are responsible for the cleavage of multiplesubstrates including the cytokeratins, PARP, alpha fodrin, NuMA and others. Caspase-7 isa 303 amino acid protein with high similarity to caspase-3. Caspase-7 occurs in threevarient forms. Granzyme B activates pro-caspase-7 to a form which can cleavepoly(ADP-ribose) polymerase (PARP) to its signature fragment of ~85 kDa. Also, in vivocaspase-7 appears to be a better substrate for granzyme B than caspase-3. Pro-caspase-7has been shown to exist as dimers or high order oligomers. Caspase-7 may be animportant intracellular effector of granzyme B-mediated apoptosis and cytotoxicT-lymophocyte-induced cell killing in vivo.
UniProt P55210
Research Area Apoptosis/Necrosis
Application Notes Western Blot: Detects proenzyme form of human Caspase-7. Positive Control: MCF-7 cell line. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.08% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Expiry Date 12 months
Supplier Images
anti-Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7) antibody anti-Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7) antibody
Background publications Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Chandler, Cohen, MacFarlane: "Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 10815-8, 1998 (PubMed).

Behrensdorf, van de Craen, Knies et al.: "The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7." in: FEBS letters, Vol. 466, Issue 1, pp. 143-7, 2000 (PubMed).

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