Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7) antibody

Details for Product No. ABIN264418
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms xCaspase-7, caspase-7, caspase7, cmh-1, ice-lap3, mch3, CASP7, AI314680, CMH-1, ICE-IAP3, Mch3, mCASP-7, CASP-7, ICE-LAP3, LICE2, MCH3, Caspase-7, MCH3/SCA-2, SCA-2
(180), (85), (64), (26), (24), (13), (12), (3), (3), (2), (1), (1), (1)
(150), (36), (2)
Clonality (Clone)
Monoclonal ()
(7), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2)
Western Blotting (WB)
(161), (73), (54), (48), (23), (20), (12), (9), (8), (3), (2)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN264418
324.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman caspase-7 protein and mouse myeloma cells. Genename: CASP7
Clone MCH3-5
Isotype IgG
Characteristics Synonyms: CASP-7, CASP7, MCH3, CMH-1, ICE-like apoptotic protease 3, Apoptotic protease Mch-3
Purification Purified
Alternative Name Caspase-7
Background Caspases are key effectors of programmed cell death. Caspase-7 along with caspase 3 and6 form the group of effector caspases that are responsible for the cleavage of multiplesubstrates including the cytokeratins, PARP, alpha fodrin, NuMA and others. Caspase-7 isa 303 amino acid protein with high similarity to caspase-3. Caspase-7 occurs in threevarient forms. Granzyme B activates pro-caspase-7 to a form which can cleavepoly(ADP-ribose) polymerase (PARP) to its signature fragment of ~85 kDa. Also, in vivocaspase-7 appears to be a better substrate for granzyme B than caspase-3. Pro-caspase-7has been shown to exist as dimers or high order oligomers. Caspase-7 may be animportant intracellular effector of granzyme B-mediated apoptosis and cytotoxicT-lymophocyte-induced cell killing in vivo.
UniProt P55210
Research Area Apoptosis/Necrosis
Application Notes Western Blot: Detects proenzyme form of human Caspase-7. Positive Control: MCF-7 cell line. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.08% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Expiry Date 12 months
Supplier Images
anti-Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7) antibody anti-Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7) antibody
Background publications Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Chandler, Cohen, MacFarlane: "Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 10815-8, 1998 (PubMed).

Behrensdorf, van de Craen, Knies et al.: "The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7." in: FEBS letters, Vol. 466, Issue 1, pp. 143-7, 2000 (PubMed).

Validation Images
Did you look for something else?
back to top