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Details for Product No. ABIN264460

Synaptosomal-Associated Protein, 25kDa (SNAP25) antibody

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Synonyms RIC-4, RIC4, SEC9, SNAP, SNAP-25, bA416N4.2, dJ1068F16.2, sp, Bdr, SNAP-25B, SNAP-25a, ric-4, ric4, sec9, snap-25
»Alternatives Cow (Bovine), Chicken, Human, Monkey, Mouse (Murine), Rat (Rattus)
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 4 references available
Catalog no. ABIN264460
Quantity 0.1 mg
313.50 $   Plus shipping costs $45.00
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Immunogen Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with ratbrain synaptosomal membranes and mouse NS1 cells.
Clone S-7B8
Isotype IgG1
Characteristics Synonyms: SNAP-25, SUP, SNAP, Super Protein, Synaptosomal-associated protein 25,Synaptosomal-associated 25 kDa protein
Purification Purified
Alternative Name SNAP25
Background SNAP25 (Synaptosome-Associated Protein of 25 kDa) is a membrane bound, pre-synapticnerve terminal protein that plays an essential role in synaptic vesicle fusion andexocytosis. It is involved in the molecular regulation of neurotransmitter release. It isthought to play an important role in the synaptic function of specific neuronal systems. SNAP25 associates with proteins involved in vesicle docking and membrane fusion. SNAP25 exists as two alternatively spliced isoforms, SNAP25A and SNAP25B. Theseisoforms are differentially expressed in neurons and neuroendocrine cells. These twoisoforms differ by 9 amino acids in the central portion of the protein.
UniProt P60880
Research Area Cancer, Neurology
Application Notes Western blot (1-5 µg/ml). Immunohistochemistry on Paraformaldehyde fixed CNS tissues (1-5 µg/ml). Does not stain reduced proteins. Positive Control: Cerebellum. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.08% Sodium Azide as preservative.
Preservative Sodium azide
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Expiry Date 12 months
Background publications Ritchie, Thomas, Coulter: "A nerve terminal protein with a selective distribution in spinal cord and brain." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 9, Issue 8, pp. 2697-709, 1989 (PubMed).

McMahon, Südhof: "Synaptic core complex of synaptobrevin, syntaxin, and SNAP25 forms high affinity alpha-SNAP binding site." in: The Journal of biological chemistry, Vol. 270, Issue 5, pp. 2213-7, 1995 (PubMed).

Zhao, Hashida, Takahashi et al.: "Cloning and sequence analysis of the human SNAP25 cDNA." in: Gene, Vol. 145, Issue 2, pp. 313-4, 1994 (PubMed).

Gerona, Larsen, Kowalchyk et al.: "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes." in: The Journal of biological chemistry, Vol. 275, Issue 9, pp. 6328-36, 2000 (PubMed).

Alternatives for antigen "Synaptosomal-Associated Protein, 25kDa (SNAP25)", type "Antibodies"
Hosts (83), (80), (10), (7), (1)
Reactivities (142), (77), (64), (23), (23), (11), (10), (9), (5), (5), (5), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (146), (77), (45), (37), (20), (15), (11), (11), (10), (10), (6), (4), (3), (2), (2)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (30), (9), (6), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)