B-Cell CLL/lymphoma 10 (BCL10) (AA 5-19) antibody

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Antigen
Synonyms CLAP, mE10, CIPER, c-E10, CARMEN, ME10, cE10, BCL-10, C81403, AI132454, BCL10
Epitope
AA 5-19
(16), (12), (7), (6), (4), (3), (2), (2), (2), (1), (1)
Reactivity
Human
(157), (57), (47), (12), (12), (12), (1)
Host
Rabbit
(97), (59), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB)
(104), (62), (39), (29), (22), (20), (19), (15), (7), (4), (2), (1)
Pubmed 6 references available
Catalog no. ABIN264992
Quantity 0.1 mg
Price
368.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide corresponding to amino acids 5 to 19 of the human BCL-10 protein.
Isotype IgG
Specificity This antibody reacts to BCL10.
Purification Purified
Alternative Name Bcl-10
Background Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP (1-6). Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-kB activation (1,2,4,6). Bcl10 interacts with caspase-9 and enhances pro- caspase-9 processing (3) and induces apoptosis through caspase-9 activation (3.6). BCL10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy (1,5). BCL10 is expressed in many human and murine tissues and cell lines (2-6).
Alternate names: B-cell CLL/lymphoma 10, BCL10, CARD-containing molecule enhancing NF-kappa-B, CARD- like apoptotic protein, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, CLAP, Cellular homolog of vCARMEN, Cellular-E10, Mammalian CARD-containing adapter molecule E10, c-E10, cCARMEN, hCLAP, mE10
Gene ID 8915
NCBI Accession NP_003912.1
UniProt O95999
Research Area Cancer
Application Notes Western Blot: 1 ug/ml. Detects a 31 kDa band in Raji whole cell lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline solution containing 0.02% sodium azide as a preservative
Preservative Sodium azide
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment The antibody can be shipped at ambient temperature. Store (in aliquots) at 2-8°C.
Expiry Date 12 months
Supplier Images
anti-B-Cell CLL/lymphoma 10 (BCL10) (AA 5-19) antibody anti-B-Cell CLL/lymphoma 10 (BCL10) (AA 5-19) antibody
Background publications Willis, Jadayel, Du et al.: "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types." in: Cell, Vol. 96, Issue 1, pp. 35-45, 1999 (PubMed).

Koseki, Inohara, Chen et al.: "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10." in: The Journal of biological chemistry, Vol. 274, Issue 15, pp. 9955-61, 1999 (PubMed).

Thome, Martinon, Hofmann et al.: "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase." in: The Journal of biological chemistry, Vol. 274, Issue 15, pp. 9962-8, 1999 (PubMed).

Yan, Lee, Schilbach et al.: "mE10, a novel caspase recruitment domain-containing proapoptotic molecule." in: The Journal of biological chemistry, Vol. 274, Issue 15, pp. 10287-92, 1999 (PubMed).

Zhang, Siebert, Yan et al.: "Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)." in: Nature genetics, Vol. 22, Issue 1, pp. 63-8, 1999 (PubMed).

Srinivasula, Ahmad, Lin et al.: "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis." in: The Journal of biological chemistry, Vol. 274, Issue 25, pp. 17946-54, 1999 (PubMed).

Hosts (97), (59), (3)
Reactivities (157), (57), (47), (12), (12), (12), (1)
Applications (104), (62), (39), (29), (22), (20), (19), (15), (7), (4), (2), (1)
Conjugates (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Epitopes (16), (12), (7), (6), (4), (3), (2), (2), (2), (1), (1)
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