BCL10 antibody (AA 1-143)

Catalog No. ABIN1944800

There are 3+ publications for this product available. The Mouse Monoclonal anti-BCL10 antibody is suitable to detect BCL10 in samples from Human. It has been validated for WB, FACS and IHC (p).

Quick Overview for BCL10 antibody (AA 1-143) (ABIN1944800)

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BCL10 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1185CT13-2-1-2

Product Details anti-BCL10 Antibody

Binding Specificity: AA 1-143

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This BCL10 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-143 amino acids from the human region of human BCL10.

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:2000. IHC-P: 1:25. IHC-P: 1:25. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-BCL10 antibody (ABIN1944800)

Koseki, Inohara, Chen, Carrio, Merino, Hottiger, Nabel, Núñez: "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10." in: The Journal of biological chemistry, Vol. 274, Issue 15, pp. 9955-61, (1999) (PubMed).

Thome, Martinon, Hofmann, Rubio, Steiner, Schneider, Mattmann, Tschopp: "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase." in: The Journal of biological chemistry, Vol. 274, Issue 15, pp. 9962-8, (1999) (PubMed).

Yan, Lee, Schilbach, Goddard, Dixit: "mE10, a novel caspase recruitment domain-containing proapoptotic molecule." in: The Journal of biological chemistry, Vol. 274, Issue 15, pp. 10287-92, (1999) (PubMed).

Target Details for BCL10

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Alternative Name: BCL10

Background: Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.

Molecular Weight: 26252

Gene ID: 8915

UniProt: O95999

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins