ADAM Metallopeptidase Domain 17 (ADAM17) (AA 807-823), (C-Term) antibody

Details for Product No. ABIN264994
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Antigen
Synonyms TACE, adam17, si:dkey-81b15.2, adam18, cd156b, csvp, tace, CD156b, Tace, ADAM18, CD156B, CSVP, NISBD
Epitope
AA 807-823, C-Term
(44), (23), (11), (8), (6), (6), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(175), (70), (67), (27), (27), (14), (1), (1), (1)
Host
Rabbit
(155), (12), (9), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB)
(145), (86), (29), (23), (20), (19), (15), (15), (9), (5), (3), (3), (2), (1)
Pubmed 6 references available
Quantity 0.1 mg
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Catalog No. ABIN264994
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Immunogen Synthetic peptide corresponding to amino acids 807 to 823 of the human TACE protein. Immunogen sequence differs from the mouse and rat sequences by one amino acid.
Isotype IgG
Specificity This antibody Detects TACE (ADAM17/CD156b).
Purification Immunoaffinity Chromatography.
Alternative Name CD156b / ADAM17
Background Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately (1-3). TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP) (4,5). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association. (6)Synonyms: CSVP, Disintegrin and metalloproteinase domain-containing protein 17, Snake venom-like protease, TACE, TNF-alpha convertase, TNF-alpha-converting enzyme
Gene ID 6868
NCBI Accession NP_003174
UniProt P78536
Research Area CD Antigens, Surface Receptors of Immune Cells, Enzymes
Application Notes Western Blot (0.25-1 μg/mL): Detects an approximately 130 kDa band in HeLa and Jurkatwhole cell lysate which may represent mature protein, precursor, and glycosylated TACE.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline solution containing 0.02 % Sodium Azide as a preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment The antibody can be shipped at ambient temperature. Store (in aliquots) at 2-8 °C.
Supplier Images
anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 807-823), (C-Term) antibody anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 807-823), (C-Term) antibody
Background publications Black, Rauch, Kozlosky et al.: "A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells." in: Nature, Vol. 385, Issue 6618, pp. 729-33, 1997 (PubMed).

Moss, Jin, Milla et al.: "Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha." in: Nature, Vol. 385, Issue 6618, pp. 733-6, 1997 (PubMed).

Giegel, Chaplin: "Targets in cytokine activation." in: Agents and actions. Supplements, Vol. 49, pp. 1-3, 1998 (PubMed).

Buxbaum, Liu, Luo et al.: "Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor." in: The Journal of biological chemistry, Vol. 273, Issue 43, pp. 27765-7, 1998 (PubMed).

Peschon, Slack, Reddy et al.: "An essential role for ectodomain shedding in mammalian development." in: Science (New York, N.Y.), Vol. 282, Issue 5392, pp. 1281-4, 1998 (PubMed).

Mizui, Yamazaki, Sagane et al.: "cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter." in: Gene, Vol. 233, Issue 1-2, pp. 67-74, 1999 (PubMed).

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