Notch Signaling

The highly-conserved Notch signaling pathway is unique, as both the Notch receptor and most of its respective ligands (canonically the DSL or Delta/Serrate/lag-2 family members) are transmembrane proteins attached to the cell surface. Therefore, Notch signaling is limited to interaction between adjacent cells.

Communication between adjacent cells is paramount, particularly during early development, when cell fate and function are yet to be determined. Notch signaling provides a method for cells to specify their own identity, and to simultaneously influence the role and identity of neighboring cells through lateral inhibition.

The core of the Notch signaling pathway involves two adjacent cells, one expressing a DSL family ligand, and the other expressing the Notch (the receptor). When receptor and ligand interact, two separate protease enzymes cleave Notch into extracellular and cytosolic components. ADAM proteases cleave the extracellular portion of Notch, which remains bound to its respective ligand and is endocytosed by the signaling cell. γ-secretase cleaves the cytosolic portion of notch. This cytosolic region migrates to the nucleus where it binds to the transcription factor CSL, transforming it from a transcriptional repressor to an activator, and upregulating expression of Notch target genes.


NOTCH1 - Notch1

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling...   More...
Antigens in this category:

Notch Antagonists

AP2A1 (Adaptor-Related Protein Complex 2, alpha 1 Subunit):

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles....   More...
Antigens in this category:
FBXW7 (F-Box and WD Repeat Domain Containing 7): FBXW7 antibodies FBXW7 ELISA Kits FBXW7 Proteins
NEDD4 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase): NEDD4 antibodies   NEDD4 Proteins
SGK1 (serum/glucocorticoid Regulated Kinase 1): SGK1 antibodies SGK1 ELISA Kits SGK1 Proteins

Notch Ligands

DLL1 (delta-Like 1):

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008].   More...
Antigens in this category:
JAG1 (Jagged 1): JAG1 antibodies JAG1 ELISA Kits JAG1 Proteins
DLL3 (delta Like Protein 3): DLL3 antibodies DLL3 ELISA Kits DLL3 Proteins
DLL4 (delta-Like 4): DLL4 antibodies DLL4 ELISA Kits DLL4 Proteins
JAG2 (Jagged 2): JAG2 antibodies JAG2 ELISA Kits JAG2 Proteins
SRRT (Serrate RNA Effector Molecule Homolog (Arabidopsis)): SRRT antibodies   SRRT Proteins

Notch Processing

FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme)):

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of...   More...
Antigens in this category:
LFNG (LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase): LFNG antibodies LFNG ELISA Kits LFNG Proteins
MFNG - Manic Fringe: MFNG antibodies MFNG ELISA Kits MFNG Proteins
POFUT1 (Protein O-Fucosyltransferase 1): POFUT1 antibodies POFUT1 ELISA Kits POFUT1 Proteins
POGLUT1 (Protein O-Glucosyltransferase 1): POGLUT1 antibodies POGLUT1 ELISA Kits POGLUT1 Proteins
RFNG (RFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase):   RFNG ELISA Kits  

Notch Directed Proteases

ADAM10 (ADAM Metallopeptidase Domain 10):

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008].   More...
Antigens in this category:
APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans)): APH1A antibodies APH1A ELISA Kits  
ADAM17 (ADAM Metallopeptidase Domain 17): ADAM17 antibodies ADAM17 ELISA Kits ADAM17 Proteins
ADAM7 (ADAM Metallopeptidase Domain 7): ADAM7 antibodies ADAM7 ELISA Kits ADAM7 Proteins
aph1b - Aph 1b: aph1b antibodies   aph1b Proteins
NCSTN - Nicastrin: NCSTN antibodies NCSTN ELISA Kits NCSTN Proteins
PSEN1 - Presenilin 1: PSEN1 antibodies PSEN1 ELISA Kits PSEN1 Proteins
PSEN2 - Presenilin 2: PSEN2 antibodies PSEN2 ELISA Kits PSEN2 Proteins
PSENEN - Presenilin Enhancer 2 Homolog (C. Elegans): PSENEN antibodies PSENEN ELISA Kits PSENEN Proteins

Pathway Agonists

CRB1 (Crumbs Homolog 1 (Drosophila)):

This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis...   More...
Antigens in this category:
DTX1 - Deltex Homolog 1: DTX1 antibodies DTX1 ELISA Kits DTX1 Proteins
NEURL1B (Neuralized Homolog 1B (Drosophila)): NEURL1B antibodies   NEURL1B Proteins
CRB2 (Crumbs Homolog 2 (Drosophila)): CRB2 antibodies   CRB2 Proteins
CRB3 (Crumbs Homolog 3 (Drosophila)): CRB3 antibodies   CRB3 Proteins
DTX3L (Deltex 3-Like (Drosophila)): DTX3L antibodies   DTX3L Proteins
DTX2 (Deltex Homolog 2 (Drosophila)): DTX2 antibodies   DTX2 Proteins
DTX3 - Deltex Homolog 3: DTX3 antibodies   DTX3 Proteins
DTX4 - Deltex Homolog 4: DTX4 antibodies   DTX4 Proteins
MIB2 (Mindbomb Homolog 2 (Drosophila)): MIB2 antibodies MIB2 ELISA Kits MIB2 Proteins
NEURL (Neuralized Homolog (Drosophila)):     NEURL Proteins

Transcription Factors

KCNJ5 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 5):

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with...   More...
Antigens in this category:
MAML1 (Mastermind-Like 1 (Drosophila)): MAML1 antibodies   MAML1 Proteins
RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region): RBPJ antibodies   RBPJ Proteins
NCOR2 (Nuclear Receptor Co-Repressor 2): NCOR2 antibodies NCOR2 ELISA Kits  
EP300 - p300: EP300 antibodies EP300 ELISA Kits EP300 Proteins