NOTCH1 - Notch1
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling... More...
NOTCH2 (Notch 2):
NOTCH3 (Notch 3):
AP2A1 (Adaptor-Related Protein Complex 2, alpha 1 Subunit):
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles.... More...
FBXW7 (F-Box and WD Repeat Domain Containing 7):
NEDD4 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase):
DLL1 (delta-Like 1):
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]. More...
JAG1 (Jagged 1):
DLL3 (delta Like Protein 3):
DLL4 (delta-Like 4):
JAG2 (Jagged 2):
FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme)):
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of... More...
LFNG (LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase):
MFNG - Manic Fringe:
POFUT1 (Protein O-Fucosyltransferase 1):
POGLUT1 (Protein O-Glucosyltransferase 1):
RFNG (RFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase):
Notch Directed Proteases
ADAM10 (ADAM Metallopeptidase Domain 10):
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]. More...
APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans)):
ADAM17 (ADAM Metallopeptidase Domain 17):
ADAM7 (ADAM Metallopeptidase Domain 7):
NCSTN - Nicastrin:
PSEN1 - Presenilin 1:
PSEN2 - Presenilin 2:
CRB1 (Crumbs Homolog 1 (Drosophila)):
This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis... More...
DTX1 - Deltex Homolog 1:
NEURL1B (Neuralized Homolog 1B (Drosophila)):
MIB2 (Mindbomb Homolog 2 (Drosophila)):
NEURL (Neuralized Homolog (Drosophila)):
KCNJ5 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 5):
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with... More...
RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region):
NCOR2 (Nuclear Receptor Co-Repressor 2):
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