TCR V Alpha24-J Alpha18 antibody (PE-Cy7)
Reactivity: Human
FACS
Host: Mouse
Monoclonal
6B11
PE-Cy7
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- Target
- TCR V Alpha24-J Alpha18
- Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- PE-Cy7
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Application
- Flow Cytometry (FACS)
- Cross-Reactivity
- Pigtailed Macaque, Sooty mangabey (Cercocebus atys), Rhesus Monkey
- Purification
- The antibody was purified by affinity chromatography and conjugated with PE/Cy7 under optimal conditions. The solution is free of unconjugated PE/Cy7 and unconjugated antibody.
- Clone
- 6B11
- Isotype
- IgG1 kappa
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protect from prolonged exposure to light. Do not freeze.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- TCR V Alpha24-J Alpha18
- Background
- Encoded by the TCR Vα24-Jα18 germline configuration, Vα24-JαQ is expressed on a subset of NKT cells, namely invariant NKT (iNKT). Vα 24-JαQ TCR interacts with the glycolipid loaded MHC class 1b molecule CD1d, inducing activation and subsequent cytokine production. iNKT cells have been implicated in immune regulation, tumor surveillance, and host response to pathogens. While iNKT cells occur at low frequency in the blood, assorted chemokines contribute to their tissue homing potential.
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