Interferon Regulatory Factor 8 (IRF8) (C-Term) antibody

Details for Product No. ABIN303274
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Antigen
Synonyms zgc:92252, IRF8, MGC140338, DKFZp469B0320, H-ICSBP, ICSBP, ICSBP1, IRF-8, icsbp1, AI893568, Icsbp1, Myls
Epitope
C-Term
(24), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(48), (26), (18), (4), (3), (2), (2), (2)
Host
Rabbit
(45), (8), (1)
Clonality
Polyclonal
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(50), (23), (8), (8), (6), (5), (1)
Pubmed 3 references available
Quantity 50 µg
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Catalog No. ABIN303274
500.50 $
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Immunogen Synthetic Peptide corresponding to 16 amino acids near the carboxy-terminus of human IRF8.
Specificity This antibody recognises Interferon Consensus Sequence Binding Protein 1 (IRF8 / ICSBP1).
Purification Immunoaffinity Chromatography.
Alternative Name IRF8 / ICSBP1
Background Interferon consensus sequence binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA binding domain in the N terminal region and a divergent C terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN alpha and IFN beta. IRF family proteins also control expression of IFN alpha and IFN beta regulated genes that are induced by viral infection. IRF8 specifically binds to the upstream regulatory region of type I IFN and IFN inducible MHC class I genes (the interferon consensus sequence (ICS)). Unlike IRF3, IRF8 appears to act as a negative regulator of IFN induced genes in most cases, but IRF8 mediates activation of NF kappaB by the toll like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells. Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia
Alternate names: IRF-8, Interferon consensus sequence-binding protein, Interferon regulatory factor 8
Gene ID 3394
NCBI Accession NP_002154
UniProt Q02556
Application Notes Immunohistochemistry on Paraffin Sections (5 ug/ml). Western Blot (1-2 ug/ml). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Phosphate Buffered Saline PBS containing 0.02% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C to -70°C for longer. Dilute only prior to immediate use.
Expiry Date 12 months
Supplier Images
anti-Interferon Regulatory Factor 8 (IRF8) (C-Term) antibody anti-Interferon Regulatory Factor 8 (IRF8) (C-Term) antibody
Background publications Weisz, Marx, Sharf et al.: "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes." in: The Journal of biological chemistry, Vol. 267, Issue 35, pp. 25589-96, 1993 (PubMed).

Cohen, Azriel, Cohen et al.: "Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome." in: The Journal of biological chemistry, Vol. 275, Issue 50, pp. 39081-9, 2001 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

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