VDAC3 antibody (N-Term)

Catalog No. ABIN309766

This Rabbit Polyclonal antibody specifically detects VDAC3 in WB and IHC. It exhibits reactivity toward Human, Rat, Mouse, Cow, Dog, Goat, Horse, Rabbit, Guinea Pig and Zebrafish (Danio rerio) and has been mentioned in 3+ publications.

Quick Overview for VDAC3 antibody (N-Term) (ABIN309766)

Target: VDAC3 (Voltage-Dependent Anion Channel 3 (VDAC3))

Reactivity: Human, Rat, Mouse, Cow, Dog, Goat, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VDAC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-VDAC3 Antibody

Binding Specificity: N-Term

Sequence: KWNTDNTLGT EISWENKLAE GLKLTLDTIF VPNTGKKSGK LKASYKRDCF

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against VDAC3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human VDAC3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 283 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-VDAC3 antibody (ABIN309766)

Majumder, Cash, Fisk: "Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis." in: Cells, Vol. 4, Issue 3, pp. 331-53, (2015) (PubMed).

Majumder, Fisk: "VDAC3 and Mps1 negatively regulate ciliogenesis." in: Cell cycle (Georgetown, Tex.), Vol. 12, Issue 5, pp. 849-58, (2013) (PubMed).

Majumder, Slabodnick, Pike, Marquardt, Fisk: "VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes." in: Cell cycle (Georgetown, Tex.), Vol. 11, Issue 19, pp. 3666-78, (2012) (PubMed).

Target Details for VDAC3

Target: VDAC3 (Voltage-Dependent Anion Channel 3 (VDAC3))

Alternative Name: VDAC3

Background: VDAC3 belongs to a group of mitochondrial membrane channels involved in translocation of adenine nucleotides through the outer membrane. These channels may also function as a mitochondrial binding site for hexokinase and glycerol kinase.VDAC3 belongs to a group of mitochondrial membrane channels involved in translocation of adenine nucleotides through the outer membrane. These channels may also function as a mitochondrial binding site for hexokinase (see HK1, MIM 142600) and glycerol kinase (GK, MIM 300474) (Rahmani et al., 1998).[supplied by OMIM]. Sequence Note: removed 1 base from the 5' end that did not align to the reference genome assembly. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1413 AF038962.1 2-1414
Alias Symbols: HD-VDAC3, VDAC-3
Protein Interaction Partner: UBC, RNF2, FBXO6, PARK2, env, ATF2, SCO2, VAPA, VAPB, LAMTOR3, SF1, VDAC2, VDAC1, UBA52, TKT, THY1, SCP2, PIN4, NDUFA7, ABCC1, EIF4A1, SERPINH1, ACAA1, Htt, TMEM256, MRPL53, SARNP, SRPRB, SUGP1, CDV3, RBM27, ATP6V1H, SBDS, YME1L1, SF3B4, PPIF, PQBP1, Tubb
Protein Size: 283

Molecular Weight: 31 kDa

Gene ID: 7419

NCBI Accession: NM_005662, NP_005653

UniProt: Q9Y277