VDAC3 antibody (N-Term)

Catalog No. ABIN2776182

Product Details anti-VDAC3 Antibody

Target: VDAC3 (Voltage-Dependent Anion Channel 3 (VDAC3))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Rabbit, Cow, Dog, Goat, Horse, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VDAC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: KWNTDNTLGT EISWENKLAE GLKLTLDTIF VPNTGKKSGK LKASYKRDCF

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against VDAC3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human VDAC3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 283 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-VDAC3 antibody (ABIN2776182)

Majumder, Cash, Fisk: "Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis." in: Cells, Vol. 4, Issue 3, pp. 331-53, (2015) (PubMed).

Majumder, Fisk: "VDAC3 and Mps1 negatively regulate ciliogenesis." in: Cell cycle (Georgetown, Tex.), Vol. 12, Issue 5, pp. 849-58, (2013) (PubMed).

Majumder, Slabodnick, Pike, Marquardt, Fisk: "VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes." in: Cell cycle (Georgetown, Tex.), Vol. 11, Issue 19, pp. 3666-78, (2012) (PubMed).

Target Details for VDAC3

Target: VDAC3 (Voltage-Dependent Anion Channel 3 (VDAC3))

Alternative Name: VDAC3 (VDAC3 Products)

Background: VDAC3 belongs to a group of mitochondrial membrane channels involved in translocation of adenine nucleotides through the outer membrane. These channels may also function as a mitochondrial binding site for hexokinase and glycerol kinase.VDAC3 belongs to a group of mitochondrial membrane channels involved in translocation of adenine nucleotides through the outer membrane. These channels may also function as a mitochondrial binding site for hexokinase (see HK1, MIM 142600) and glycerol kinase (GK, MIM 300474) (Rahmani et al., 1998).[supplied by OMIM]. Sequence Note: removed 1 base from the 5' end that did not align to the reference genome assembly. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1413 AF038962.1 2-1414
Alias Symbols: HD-VDAC3, VDAC-3
Protein Interaction Partner: UBC, RNF2, FBXO6, PARK2, env, ATF2, SCO2, VAPA, VAPB, LAMTOR3, SF1, VDAC2, VDAC1, UBA52, TKT, THY1, SCP2, PIN4, NDUFA7, ABCC1, EIF4A1, SERPINH1, ACAA1, Htt, TMEM256, MRPL53, SARNP, SRPRB, SUGP1, CDV3, RBM27, ATP6V1H, SBDS, YME1L1, SF3B4, PPIF, PQBP1, Tubb
Protein Size: 283

Molecular Weight: 31 kDa

Gene ID: 7419

NCBI Accession: NM_005662, NP_005653

UniProt: Q9Y277