DEAF1 antibody (N-Term)
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- Target See all DEAF1 Antibodies
- DEAF1 (Deformed Epidermal Autoregulatory Factor 1 (Drosophila) (DEAF1))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Guinea Pig, Dog, Cow, Saccharomyces cerevisiae
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DEAF1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EEPVLSRDED SEEDADSEAE RETPRVTAVA VMAAEPGHMD MGAEALPGPD
- Predicted Reactivity
- Cow: 83%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Yeast: 100%
- Characteristics
- This is a rabbit polyclonal antibody against DEAF1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human DEAF1
- Top Product
- Discover our top product DEAF1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 565 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- DEAF1 (Deformed Epidermal Autoregulatory Factor 1 (Drosophila) (DEAF1))
- Alternative Name
- DEAF1 (DEAF1 Products)
- Background
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DEAF1 down-regulates transcription of those genes by binding to sequence with multiple copies of TTC[CG]G present in their own promoter and that of the HNRPA2B1 gene. DEAF1 binds to the retinoic acid response element (RARE) AGGGTTCACCGAAAGTTCA. DEAF1 activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.
Alias Symbols: NUDR, SPN, ZMYND5
Protein Interaction Partner: IRF7, IRF3, CREB1, PELI1, PELI2, HRSP12, GSK3B, GSK3A, CDKN2A, PPP1CC, PPP1CA, CDC37, AIMP2, TK1, RAD23B, PIN1, HRAS, FHL1, CDKN1A, ASCC2, INTS1, LMO4, DEAF1,
Protein Size: 565 - Molecular Weight
- 59 kDa
- Gene ID
- 10522
- NCBI Accession
- NM_021008, NP_066288
- UniProt
- O75398
- Pathways
- Tube Formation
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