Deformed Epidermal Autoregulatory Factor 1 (Drosophila) (DEAF1) (N-Term) antibody

Details for Product No. ABIN309945
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Antigen
Synonyms CG8567, DEAF-1, DEAF1, Deaf-1, Dmel\\CG8567, deaf1, l(3)76BDv, spn, nudr, zmynd5, NUDR, SPN, ZMYND5, AU042387, C230009B13Rik, MYND5
Epitope
N-Term
(20), (8), (7), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Fruit Fly (Drosophila melanogaster), Human
(46), (17), (14), (12), (12), (11), (11)
Host
Rabbit
(43), (16)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(46), (25), (9), (4), (3), (3), (2), (2), (2)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN309945
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human DEAF1
Sequence EEPVLSRDED SEEDADSEAE RETPRVTAVA VMAAEPGHMD MGAEALPGPD
Predicted Reactivity Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Dog : 90 %, Pig : 90 %
Characteristics This is a rabbit polyclonal antibody against DEAF1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name DEAF1
Background DEAF1 down-regulates transcription of those genes by binding to sequence with multiple copies of TTC[CG]G present in their own promoter and that of the HNRPA2B1 gene. DEAF1 binds to the retinoic acid response element (RARE) AGGGTTCACCGAAAGTTCA. DEAF1 activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.
Molecular Weight 59 kDa
Gene ID 10522
NCBI Accession NP_066288, NM_021008
UniProt O75398
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 565 AA
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Czesak, Lemonde, Peterson et al.: "Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 6, pp. 1864-71, 2006 (PubMed).

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