Methionine Adenosyltransferase I, alpha (MAT1A) (C-Term) antibody

Details for Product No. ABIN310139
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Antigen
Synonyms E130115E11Rik, MAT1, P36, wu:fi35e01, zgc:55442, MAT, MATA1, SAMS, SAMS1, AI046368, AdoMet, Ams, SADE, SAS, HMAT1, HUMMAT1H, MAT1H, PEA-15, PED
Epitope
C-Term
(10), (8), (4), (3), (2)
Reactivity
Dog (Canine), Mouse (Murine), Rat (Rattus), Cow (Bovine), Xenopus laevis, Pig (Porcine), Zebrafish (Danio rerio), Human, Chicken
(32), (12), (12), (3), (2), (2), (1), (1), (1)
Host
Rabbit
(26), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(32), (22), (12), (3), (3), (1), (1)
Pubmed 1 reference available
Quantity 100 µg
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Catalog No. ABIN310139
229.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human MAT1A
Sequence VAKSLVKAGL CRRVLVQVSY AIGVAEPLSI SIFTYGTSQK TERELLDVVH
Predicted Reactivity Dog : 100 %, Pig : 90 %, Rat : 90 %, Chicken : 80 %, Rabbit : 80 %
Characteristics This is a rabbit polyclonal antibody against MAT1A. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name MAT1A
Background MAT1A catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. MAT1A is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in its gene are associated with methionine adenosyltransferase deficiency.This gne encodes methionine adenosyltransferase I (alpha isoform), which catalyzes the formation of S-adenosylmethionine from methionine and ATP. Methionine adenosyltransferase deficiency is caused by recessive and dominant mutations, the latter identified in autosomal dominant persistant hypermethioninemia.
Molecular Weight 44 kDa
Gene ID 4143
NCBI Accession NM_000429, NP_000420
UniProt Q00266
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 395 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Oh, Yang, Hahn et al.: "Transcriptome analysis of human gastric cancer." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 16, Issue 12, pp. 942-54, 2005 (PubMed).

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