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MAT1A Products

(Methionine Adenosyltransferase I, alpha (MAT1A))

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This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008].

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Featured MAT1A Categories

MAT1A Antibodies

High quality antibodies with extensive validation data.

MAT1A ELISA Kits

Reliable ELISA kits for a wide range of species.

MAT1A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MAT1A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IP
Validations
  • (4)
Cat. No. ABIN517744
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC, IF
Validations
  • (3)
Cat. No. ABIN6263141
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
  • (2)
Cat. No. ABIN656632
Quantity 400 μL
Datasheet Datasheet

Recommended MAT1A ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968589
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968588
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968587
Quantity 96 tests
Datasheet Datasheet

Recommended MAT1A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123931
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310436
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310434
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our MAT1A products

Fling, Doskey, Fader, Nault, Zacharewski: "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice." in: Scientific reports, Vol. 10, Issue 1, pp. 14831, (2021) (PubMed).

Kang, Kim, Goo, Jeong, An, Hwang: "Unraveling the role of quorum sensing-dependent metabolic homeostasis of the activated methyl cycle in a cooperative population of Burkholderia glumae." in: Scientific reports, Vol. 9, Issue 1, pp. 11038, (2019) (PubMed).

Song, Li, Wang, Du, Yang: "DMBA acts on cumulus cells to desynchronize nuclear and cytoplasmic maturation of pig oocytes." in: Scientific reports, Vol. 7, Issue 1, pp. 1687, (2018) (PubMed).

Jiang, Hurt, Breen, Stabler, Allen, Orlicky, Maclean: "Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap." in: Biology open, Vol. 4, Issue 9, pp. 1154-62, (2015) (PubMed).

Bing, Zhu, Yu, Li, Liu, Li, Wang, Qi, Guo, Yuan, He, Liu, Liu: "Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells." in: The Journal of biological chemistry, Vol. 289, Issue 47, pp. 32639-55, (2014) (PubMed).

Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

Geillinger, Rathmann, Köhrle, Fiamoncini, Daniel, Kipp: "Hepatic metabolite profiles in mice with a suboptimal selenium status." in: The Journal of nutritional biochemistry, Vol. 25, Issue 9, pp. 914-22, (2014) (PubMed).

Cheng, Zhou, Li, Li, Li, Li, Lu: "Methotrexate and 5-aminoimidazole-4-carboxamide riboside exert synergistic anticancer action against human breast cancer and hepatocellular carcinoma." in: Acta pharmacologica Sinica, Vol. 34, Issue 7, pp. 951-9, (2013) (PubMed).

Yang, Cho, Li, Peng, Ko, Mato, Lu: "MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma." in: The Journal of clinical investigation, Vol. 123, Issue 1, pp. 285-98, (2013) (PubMed).

Guo, Liu, Zhong, Wang, Wang, Xia: "Cyanidin-3-O-?-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells." in: Lipids in health and disease, Vol. 11, pp. 10, (2012) (PubMed).

Synonyms and alternative names related to MAT1A

methionine adenosyltransferase 1A (MAT1A), methionine adenosyltransferase 1A (Mat1a), methionine adenosyltransferase I, alpha (Mat1a), methionine adenosyltransferase I, alpha (mat1a), AdoMet, AI046368, Ams, MAT, MATA1, SADE, SAMS, SAMS1, SAS, wu:fi35e01, zgc:55442

Protein level used designations for MAT1A

  • MAT 1
  • MAT-I/III
  • S-adenosylmethionine synthase isoform type-1
  • S-adenosylmethionine synthetase isoform type-1
  • adoMet synthase 1
  • adoMet synthetase 1
  • methionine adenosyltransferase 1
  • methionine adenosyltransferase I/III
  • S - adenosylmethionine synthetase
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