STEAP Family Member 3, Metalloreductase (STEAP3) (N-Term) antibody

Details for Product No. ABIN310477
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Antigen
Synonyms STEAP3, 1010001D01Rik, Tsap6, pHyde, AHMIO2, STMP3, TSAP6, dudlin-2
Epitope
N-Term
(10), (10), (8), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Human
(33), (18), (18)
Host
Rabbit
(33)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(33), (18), (13), (5), (3)
Pubmed 1 reference available
Quantity 100 µg
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Catalog No. ABIN310477
229.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human STEAP3
Sequence LVGSGFKVVV GSRNPKRTAR LFPSAAQVTF QEEAVSSPEV IFVAVFREHY
Predicted Reactivity Human : 100 %, Mouse : 100 %, Horse : 90 %, Rabbit : 90 %, Bovine : 80 %, Guinea pig : 80 %, Dog : 70 %
Characteristics This is a rabbit polyclonal antibody against STEAP3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name STEAP3
Background AS an endosomal ferrireductase, STEAP3 is required for efficient transferrin-dependent iron uptake in erythroid cells. It participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+) and can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. STEAP3 uses NAD(+) as acceptor (By similarity). It may play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. STEAP3 is indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCT
Molecular Weight 54 kDa
Gene ID 55240
NCBI Accession NP_001008410, NM_001008410
UniProt Q658P3
Research Area Signaling, Metabolism
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 488 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-STEAP Family Member 3, Metalloreductase (STEAP3) (N-Term) antibody WB Suggested Anti-STEAP3 Antibody Titration: 5.0ug/ml
Positive Control: HepG2 cell lysate
Background publications Amzallag, Passer, Allanic et al.: "TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway." in: The Journal of biological chemistry, Vol. 279, Issue 44, pp. 46104-12, 2004 (PubMed).

Validation Images
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