Chromatin Licensing and DNA Replication Factor 1 (CDT1) (C-Term) antibody

Details for Product No. ABIN310811
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Synonyms DUP, RIS2, Ris2, C76791, AW545653, 2610318F11Rik, dup, ris2, xcdt1, CDT1, fc37h07, im:7158083, wu:fc37h07, wu:fi38h09
(5), (1)
Mouse (Murine), Rat (Rattus), Cow (Bovine), Human
(15), (3), (3)
(10), (6)
Immunohistochemistry (IHC), Western Blotting (WB)
(15), (5), (2), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN310811
Quantity 50 µg
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Immunogen Synthetic peptide directed towards the C terminal of human CDT1
Predicted Reactivity Human : 100 %, Mouse : 100 %, Pig : 100 %, Rat : 100 %, Bovine : 90 %, Rabbit : 90 %
Characteristics This is a rabbit polyclonal antibody against CDT1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name CDT1
Background CDT1 cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. It binds DNA in a sequence-, strand-, and conformation-independent manner and is a potential oncogene.
Molecular Weight 60 kDa
Gene ID 81620
NCBI Accession NM_030928, NP_112190
UniProt Q9H211
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA
Application Notes Optimal working dilutions should be determined experimentally by the investigator.

Antigen size: 546 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Chromatin Licensing and DNA Replication Factor 1 (CDT1) (C-Term) antibody WB Suggested Anti-CDT1 Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysate
anti-Chromatin Licensing and DNA Replication Factor 1 (CDT1) (C-Term) antibody (2) Sample Type: 3. rat brain extract (80ug)
Primary Antibody Dilution: 2ug/ml
Secondary Antibody: IRDye 800CW goat anti-rabbit from Li-COR Bioscience
Secondary Antibody Dilution: 1: 20,000
Image Submitted by: Yuzhi Chen
University of Arkansas for Medical Science
Background publications Hu, Xiong: "An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage." in: The Journal of biological chemistry, Vol. 281, Issue 7, pp. 3753-6, 2006 (PubMed).

Hosts (10), (6)
Reactivities (15), (3), (3)
Applications (15), (5), (2), (1), (1)
Epitopes (5), (1)
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