Zinc Metalloproteinase, Ste24 (Zmpste24) (N-Term) antibody

Details for Product No. ABIN310835
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Antigen
Synonyms DDBDRAFT_0189115, DDBDRAFT_0237846, DDB_0189115, DDB_0237846, F2N1.21, F2N1_21, STE24, FACE-1, FACE1, HGPS, PRO1, Ste24p, A530043O15Rik, D030046F19, Face-1, MADB, fi45a02, wu:fi45a02, zgc:55655
Epitope
N-Term
(22), (9), (8), (7), (6), (5), (2), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Zebrafish (Danio rerio), Human
(44), (4), (2), (1), (1)
Host
Rabbit
(42), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Application
Western Blotting (WB)
(45), (20), (12), (7)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN310835
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human ZMPSTE24
Sequence LYSETEGTLI LLFGGIPYLW RLSGRFCGYA GFGPEYEITQ SLVFLLLATL
Predicted Reactivity Bovine : 100 %, Horse : 100 %, Rabbit : 100 %, Dog : 90 %, Chicken : 90 %, Zebrafish : 90 %, Mouse : 70 %, Rat : 70 %
Characteristics This is a rabbit polyclonal antibody against ZMPSTE24. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ZMPSTE24
Background ZMPSTE24 is a member of the peptidase M48A family. This protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in ZMPSTE24 gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.The protein encoded by this gene is a zinc metalloprotease similar to yeast Ste24p. It is an integral membrane protein belonging to peptidase family M48 and is found in the endoplasmic reticulum and possibly in the Golgi compartment. It is thought to be involved in the proteolytic processing of farnesylated proteins.
Molecular Weight 55 kDa
Gene ID 10269
NCBI Accession NM_005857, NP_005848
UniProt O75844
Research Area Proteolysis / Ubiquitin, Cytoskeleton
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 475 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Zinc Metalloproteinase, Ste24 (Zmpste24) (N-Term) antibody WB Suggested Anti-ZMPSTE24 Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate
Background publications Moulson, Go, Gardner et al.: "Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy." in: The Journal of investigative dermatology, Vol. 125, Issue 5, pp. 913-9, 2005 (PubMed).

Validation Images
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