IL12B antibody
-
- Target See all IL12B Antibodies
- IL12B (Interleukin 12 beta (IL12B))
-
Reactivity
- Human, Sheep, Cow
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This IL12B antibody is un-conjugated
-
Application
- Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Functional Studies (Func)
- Specificity
- This antibody recognizes Interleukin-12. It has been shown to block the biological activity of IL-12.
- Characteristics
- Synonyms: Interleukin-12B, IL-12B, IL-12 subunit p40, CLMF p40, NKSF2, Cytotoxic lymphocytematuration factor 40 kDa subunit, NK cell stimulatory factor chain 2
- Purification
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Immunogen
- Recombinant bovine IL-12
- Clone
- CC326
- Isotype
- IgG2b
- Top Product
- Discover our top product IL12B Primary Antibody
-
anti-Interleukin 12 beta (IL12B) (AA 30-320) antibody
IL12B Reactivity: Human WB, IHC, IP, ICC Host: Mouse Monoclonal C2 unconjugated
anti-Interleukin 12 beta (IL12B) (AA 23-327) antibodyIL12B Reactivity: Sheep WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Interleukin 12 beta (IL12B) (AA 23-328) antibodyIL12B Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Interleukin 12 beta (IL12B) (AA 201-300) antibodyIL12B Reactivity: Human, Mouse WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Interleukin 12 beta (IL12B) (AA 264-290), (C-Term) antibodyIL12B Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB28444 unconjugated
anti-Interleukin 12 beta (IL12B) (Internal Region) antibodyVerified IL12B Reactivity: Human WB, ELISA Host: Goat Polyclonal unconjugated
anti-Interleukin 12 beta (IL12B) (Internal Region) antibodyVerified IL12B Reactivity: Mouse, Rat WB, ELISA Host: Goat Polyclonal unconjugated
anti-Interleukin 12 beta (IL12B) (AA 229-328) antibodyIL12B Reactivity: Human WB, ELISA Host: Mouse Monoclonal 2H6 unconjugated
anti-Interleukin 12 beta (IL12B) (AA 35-302) antibodyIL12B Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Interleukin 12 beta (IL12B) (C-Term) antibodyIL12B Reactivity: Human, Mouse WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
-
- Application Notes
-
ELISA: 1/100 - 1/1000. Flow cytometry: 1/1000, use 10 μL to label 10^6 cells of 100 l. Functional assays: 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- PBS, pH 7.4, None, None
- Preservative
- Azide free
- Storage
- -20 °C
- Storage Comment
-
Store the antibody undiluted at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch. - Expiry Date
- 12 months
-
- Target
- IL12B (Interleukin 12 beta (IL12B))
- Alternative Name
- Interleukin-12 beta / IL12B (IL12B Products)
- Background
- Interleukin 12 (IL12) can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine activated killer cells, and stimulate the production of IFN gamma by resting PBMC. IL12 induces IFN gamma, TNF alpha production in T and NK cells, costimulation of PBL proliferation, proliferation/differentiation of TH1 T lymphocytes. It is downregulated by IL10, homodimeric p40 antagonistic to functional p70 heterodimer. IL12R beta 1 binds p40 but when dimeric with IL12R beta 2 binds p35.Synonyms: CLMF p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, IL-12B, Interleukin-12B, NK cell stimulatory factor chain 2, NKSF2
- Gene ID
- 281857
- UniProt
- P46282
- Pathways
- JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
-
