BMI1 Polycomb Ring Finger Oncogene (BMI1) (Middle Region) antibody

Details for Product No. ABIN318769
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Antigen
Synonyms bmi1, pcgf4, psc1, wu:fb17g03, wu:fd18f06, FLVI2/BMI1, PCGF4, RNF51, AW546694, Bmi-1, Pcgf4, BMI-1
Epitope
Middle Region
(13), (12), (9), (7), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(146), (59), (45), (19), (19), (17), (5), (4), (3), (2), (1), (1)
Host
Rabbit
(109), (39), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (7), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(139), (65), (39), (32), (30), (19), (10), (9), (8), (6), (6), (4), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN318769
390.50 $
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Immunogen 15 amino acid peptide sequence near the centre of human BMI-1.
Isotype IgG
Specificity This antibody recognises 37 kDa polycomb complex protein BMI-1, involved in segment specification, cell growth and maintenance, transcriptional regulation and chromatin modification.
Purification Purified
Alternative Name BMI-1 / RNF51
Background BMI-1 is a proto-oncogene which cooperates with the myc oncogene to produce B-lymphomas. It is required in the regulation of normal adult and leukaemic stem cells, making BMI-1 a potential target for stem cell proliferation and anti-cancer therapies. BMI-1 represses transcription at the ink4 locus which contains tumour suppressors p16 and p19Arf. BMI-1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex which ubiquitinates histone-2A at lys119, resulting in a heritable change in the ability of chromatin to express genes. BMI-1 is also required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2 within the PRC1 complex.Synonyms: BMI1, PCGF4, Polycomb group RING finger protein 4, RING finger protein 51
Gene ID 100532731
NCBI Accession NP_001190991
UniProt P35226
Application Notes Western Blot: 0.5 - 1.0g/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline containing 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (Middle Region) antibody anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (Middle Region) antibody
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (Middle Region) antibody (2) anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (Middle Region) antibody (Image 2)
Background publications Lessard, Sauvageau: "Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells." in: Nature, Vol. 423, Issue 6937, pp. 255-60, 2003 (PubMed).

Validation Images
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