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HDAC4/HDAC5/HDAC9 (pSer220), (pSer246), (pSer259) antibody

Details for Product No. ABIN319280, Supplier: Log in to see
Antigen
Epitope
pSer220, pSer246, pSer259
7
7
7
1
1
1
Reactivity
Human, Mouse (Murine)
10
8
Host
Rabbit
10
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
10
8
4
2
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human HDAC4/HDAC5/HDAC9 around the phosphorylation site of Serine 246/259/220 (T-A-SP-EP).
Purification Immunoaffinity Chromatography: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Background Synonyms: HDAC-4, HDAC-5, HDAC-9, Histone Deacetylase
Application Notes Western Blot (1/500-1/1000). Immunohistochemistry (1/50-1/100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.
Supplier Images
 image for anti-HDAC4/HDAC5/HDAC9 (pSer220), (pSer246), (pSer259) antibody (ABIN319280) anti-HDAC4/HDAC5/HDAC9 (pSer220), (pSer246), (pSer259) antibody
 image for anti-HDAC4/HDAC5/HDAC9 (pSer220), (pSer246), (pSer259) antibody (ABIN319280) anti-HDAC4/HDAC5/HDAC9 (pSer220), (pSer246), (pSer259) antibody (Image 2)
Background publications Vigushin, Coombes: "Targeted histone deacetylase inhibition for cancer therapy." in: Current cancer drug targets, Vol. 4, Issue 2, pp. 205-18, 2004 (PubMed).

Thiagalingam, Cheng, Lee et al.: "Histone deacetylases: unique players in shaping the epigenetic histone code." in: Annals of the New York Academy of Sciences, Vol. 983, pp. 84-100, 2003 (PubMed).

Marmorstein: "Structure and function of histone acetyltransferases." in: Cellular and molecular life sciences : CMLS, Vol. 58, Issue 5-6, pp. 693-703, 2001 (PubMed).

Cress, Seto: "Histone deacetylases, transcriptional control, and cancer." in: Journal of cellular physiology, Vol. 184, Issue 1, pp. 1-16, 2000 (PubMed).