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Details for Product No. ABIN319372

Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) (N-Term) antibody

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Antigen
Synonyms PP2Ac, PP2CA, PP2Calpha, RP-C, PP2A, R75353, Pp2a1, PPP2CA, pp2ac, Ppp2ca, pp2ca, rp-c, zgc:110641
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN319372
Quantity 50 µg
Price
242.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen The antiserum was produced against a synthesized peptide Corresponding to the amino terminal sequence from human PP2A-alpha protein (''KQLSESQVKSL'').
Specificity PP2A-alpha antibody detects endogenous levels of total PP2A-alpha protein.
Purification Immunoaffinity Chromatography.
Alternative Name PPP2CA
Background Protein phosphatase 2A (PP2A) is the most abundant phosphatase specific for serine and threonine phosphorylation in mammalian cells. Dephosphorylation of substrates targeted by PP2A plays a vital role in a large variety of cellular processes including signal transduction, regulation of the cell cycle, gene expression and development. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit alpha serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory beta subunit.
Alternate names: PP2A-alpha, Protein Phospatase 2A, Replication protein C, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Gene ID 5515
NCBI Accession NP_002706.1
UniProt P67775
Application Notes Western Blot (1/500-1/1000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20°C.
Expiry Date 12 months
Background publications Tolstykh, Lee, Vafai et al.: "Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits." in: The EMBO journal, Vol. 19, Issue 21, pp. 5682-91, 2000 (PubMed).

Yu, Du, Moreno et al.: "Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen." in: Molecular biology of the cell, Vol. 12, Issue 1, pp. 185-99, 2001 (PubMed).

Janssens, Goris: "Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling." in: The Biochemical journal, Vol. 353, Issue Pt 3, pp. 417-39, 2001 (PubMed).

Alternatives for antigen "Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA)", type "Antibodies"
Hosts (61), (15), (2), (2), (1)
Reactivities (76), (43), (42), (14), (12), (12), (11), (1)
Applications (69), (27), (20), (18), (17), (13), (9), (7), (2)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (14), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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