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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (C-Term) antibody

Details for Product No. ABIN334499, Supplier: Log in to see
Antigen
  • ABC36
  • HHF1
  • HI
  • HRINS
  • MRP8
  • PHHI
  • SUR
  • SUR1
  • SUR1delta2
  • TNDM2
  • D930031B21Rik
  • Sur
  • Sur1
Epitope
C-Term
47
36
18
4
4
2
2
2
1
1
Reactivity
Human
48
34
33
19
2
2
2
1
1
1
Host
Goat
49
15
12
Clonality
Polyclonal
Conjugate
Un-conjugated
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
Methode Type
Peptide ELISA
Application
ELISA, Western Blotting (WB)
70
46
36
21
18
3
3
2
2
1
1
Supplier
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Immunogen Peptide with sequence C-EFDKPEKLLSRKD, from the C Terminus of the protein sequence according to NP_000343.2.
Blocking Peptide Blocking peptide for this product available: ABIN368979
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name SUR1 / ABCC8 (ABCC8 Antibody Abstract)
Background Synonyms: ABCC8, SUR1, ATP-binding cassette, sub-family C (CFTR/MRP), member 8, ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, TNDM2, ATP-binding cassette, sub-family C, member 8, sulfonylurea receptor (hyperinsulinemia)
Gene ID 6833, 20927, 25559
NCBI Accession NP_000343
Pathways
Application Notes ELISA: antibody detection limit dilution 1:8000.
Western blot: Approx 170 kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 177 kDa according to NP_000343.2). Recommended concentration: 0.5-1.5 µg/mL. An additional band of unknown identity was also consistently observed at 23 kDa. This band was successfully blocked by incubation with the immunising peptide.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
 image for anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (C-Term) antibody (ABIN334499) ABIN334499 (0.5µg/ml) staining of Human Cerebellum lysate (35µg protein in RIPA buffe...
Background publications de Wet, Rees, Shimomura et al.: "Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 48, pp. 18988-92, 2007 (PubMed).