ABCC8 Products
(ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
Categories
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed\; however, the transcript variants have not been fully described. [provided by RefSeq, Jul 2008].
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Featured ABCC8 Categories
ABCC8 Antibodies
High quality antibodies with extensive validation data.
ABCC8 ELISA Kits
Reliable ELISA kits for a wide range of species.
ABCC8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ABCC8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, ICC, IHC (p), IHC (fro)
Validations
- (3)
Cat. No.
ABIN7441085
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN1027723
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN2482997
Quantity
100 μg
Datasheet
Datasheet
Recommended ABCC8 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953985
Quantity
96 tests
Datasheet
Datasheet
Recommended ABCC8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305467
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3087972
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3087970
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ABCC8 products
: "Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion." in: Journal of neurotrauma, Vol. 36, Issue 7, pp. 1060-1079, (2019) (PubMed).: "Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice." in: International journal of molecular sciences, Vol. 20, Issue 9, (2019) (PubMed).
: "Expression of KATP channels in human cervical cancer: Potential tools for diagnosis and therapy." in: Oncology letters, Vol. 15, Issue 5, pp. 6302-6308, (2018) (PubMed).
: "Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters." in: Toxicology and applied pharmacology, Vol. 310, pp. 215-228, (2016) (PubMed).
: "Alternating hypoglycemia and hyperglycemia in a toddler with a homozygous p.R1419H ABCC8 mutation: an unusual clinical picture." in: Journal of pediatric endocrinology & metabolism : JPEM, Vol. 28, Issue 3-4, pp. 345-51, (2015) (PubMed).
: "Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells." in: Stem cell research, Vol. 12, Issue 1, pp. 194-208, (2014) (PubMed).
: "Endocytosis of HERG is clathrin-independent and involves arf6." in: PLoS ONE, Vol. 8, Issue 12, pp. e85630, (2014) (PubMed).
: "Decomposition of slide helix contributions to ATP-dependent inhibition of Kir6.2 channels." in: The Journal of biological chemistry, Vol. 288, Issue 32, pp. 23038-49, (2013) (PubMed).
: "Leptin promotes K(ATP) channel trafficking by AMPK signaling in pancreatic ?-cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 31, pp. 12673-8, (2013) (PubMed).
: "Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 48, pp. 18988-92, (2007) (PubMed).
Synonyms and alternative names related to ABCC8
ATP binding cassette subfamily C member 8 (ABCC8), ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (Abcc8), ATP binding cassette subfamily C member 8 (Abcc8), ABC36, D930031B21Rik, HHF1, HI, HRINS, MRP8, PHHI, SUR, Sur, SUR1, Sur1, SUR1delta2, TNDM2Protein level used designations for ABCC8
- ATP-binding cassette, sub-family C (CFTR/MRP), member 8
- ATP-binding cassette, sub-family C, member 8
- ATP-binding cassette sub-family C member 8
- ATP-binding cassette transporter sub-family C member 8
- sulfonylurea receptor (hyperinsulinemia)
- sulfonylurea receptor 1
- sulfonylurea receptor
- sulphonylurea receptor 1
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