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Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I) (Cytoplasmic Domain) antibody
|Synonyms||Cav3.3, KIAA1120, CACNA1I, CACNA1L, Ca(v)3.3, si:ch211-51h13.1|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||CACNA1I (Cav3.3)|
|Immunogen||A synthetic peptide from a cytoplasmic domain of human CACNA1I (Cav3.3) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.|
|Description||Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H. Subcellular location: Membrane; Multi-pass membrane protein. Tissue specificity: Brain specific Also known as: Voltage-dependent T-type calcium channel subunit alpha-1I, Voltage-gated calcium channel subunit alpha Cav3.3.|
|Specificity||Appears to be specific for CACNA1I.|
|Application Notes||IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Mittman, Guo, Emerick et al.: "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit." in: Neuroscience letters, Vol. 269, Issue 3, pp. 121-4, 1999 (PubMed).
Dunham, Shimizu, Roe et al.: "The DNA sequence of human chromosome 22." in: Nature, Vol. 402, Issue 6761, pp. 489-95, 1999 (PubMed).
Monteil, Chemin, Leuranguer et al.: "Specific properties of T-type calcium channels generated by the human alpha 1I subunit." in: The Journal of biological chemistry, Vol. 275, Issue 22, pp. 16530-5, 2000 (PubMed).
Gomora, Murbartiuan, Arias et al.: "Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation." in: Biophysical journal, Vol. 83, Issue 1, pp. 229-41, 2002 (PubMed).
Zhang, Chen, Saraf et al.: "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity." in: The Journal of biological chemistry, Vol. 281, Issue 31, pp. 22332-41, 2006 (PubMed).
|Hosts||Rabbit (9), Mouse (1)|
|Reactivities||Human (7), Rat (Rattus) (2), Dog (Canine) (1), Mouse (Murine) (1), Zebrafish (1)|
|Applications||Western Blotting (WB) (10), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2), ELISA (1), Immunohistochemistry (Fixed) (IHC (fx)) (1), Immunohistochemistry (IHC) (1)|
|Epitopes||Cytoplasmic Domain (2), Internal Region (1)|