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Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I) (Cytoplasmic Domain) antibody

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Synonyms CACNA1L, Ca(V)3.3, Cav3.3, ca(v)3.3, si:ch211-51h13.1, Ca(v)3.3
Cytoplasmic Domain
(3), (2), (2), (2), (2), (2), (1), (1)
Human, Rat (Rattus), Mouse (Murine)
(20), (10), (8), (1), (1)
(16), (5)
Immunohistochemistry (IHC), Western Blotting (WB)
(17), (6), (6), (1)
Pubmed 5 references available
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Quantity 500 μg
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from a cytoplasmic domain of human CACNA1I conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Isotype IgG
Specificity Specific for CACNA1I.
Alternative Name CACNA1I (CACNA1I Antibody Abstract)
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Brain specific Also known as: Voltage-dependent T-type calcium channel subunit alpha-1I, Voltage-gated calcium channel subunit alpha Cav3.3.
Research Area Signaling
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Zhang, Chen, Saraf et al.: "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity." in: The Journal of biological chemistry, Vol. 281, Issue 31, pp. 22332-41, 2006 (PubMed).

Gomora, Murbartiuan, Arias et al.: "Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation." in: Biophysical journal, Vol. 83, Issue 1, pp. 229-41, 2002 (PubMed).

Monteil, Chemin, Leuranguer et al.: "Specific properties of T-type calcium channels generated by the human alpha 1I subunit." in: The Journal of biological chemistry, Vol. 275, Issue 22, pp. 16530-5, 2000 (PubMed).

Dunham, Shimizu, Roe et al.: "The DNA sequence of human chromosome 22. ..." in: Nature, Vol. 402, Issue 6761, pp. 489-95, 1999 (PubMed).

Mittman, Guo, Emerick et al.: "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit." in: Neuroscience letters, Vol. 269, Issue 3, pp. 121-4, 1999 (PubMed).

Catalog No. ABIN350147
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