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Details for Product No. ABIN350147

Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I) (Cytoplasmic Domain) antibody

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Antigen
Synonyms Cav3.3, ca(v)3.3, Ca(v)3.3, si:ch211-51h13.1, Ca(V)3.3, CACNA1L
Epitope
»Alternatives Cytoplasmic Domain
Reactivity
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350147
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from a cytoplasmic domain of human CACNA1I (Cav3.3) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
Isotype IgG
Specificity Appears to be specific for CACNA1I.
Purity IgG
Alternative Name CACNA1I (Cav3.3)
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Brain specific Also known as: Voltage-dependent T-type calcium channel subunit alpha-1I, Voltage-gated calcium channel subunit alpha Cav3.3.
UniProt Q9P0X4
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Mittman, Guo, Emerick et al.: "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit." in: Neuroscience letters, Vol. 269, Issue 3, pp. 121-4, 1999 (PubMed).

Dunham, Shimizu, Roe et al.: "The DNA sequence of human chromosome 22." in: Nature, Vol. 402, Issue 6761, pp. 489-95, 1999 (PubMed).

Monteil, Chemin, Leuranguer et al.: "Specific properties of T-type calcium channels generated by the human alpha 1I subunit." in: The Journal of biological chemistry, Vol. 275, Issue 22, pp. 16530-5, 2000 (PubMed).

Gomora, Murbartiuan, Arias et al.: "Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation." in: Biophysical journal, Vol. 83, Issue 1, pp. 229-41, 2002 (PubMed).

Zhang, Chen, Saraf et al.: "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity." in: The Journal of biological chemistry, Vol. 281, Issue 31, pp. 22332-41, 2006 (PubMed).

Alternatives for antigen "Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I)", type "Antibodies"
Hosts (11), (3)
Reactivities (13), (4), (3), (1), (1)
Applications (14), (3), (3), (1), (1), (1)
Epitopes (2), (2), (1), (1)
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