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CACNA1I antibody (Cytoplasmic Domain)

CACNA1I Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN350147
  • Target See all CACNA1I Antibodies
    CACNA1I (Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I))
    Binding Specificity
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Domain
    Reactivity
    • 9
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 8
    • 2
    Rabbit
    Clonality
    • 8
    • 2
    Polyclonal
    Conjugate
    • 10
    This CACNA1I antibody is un-conjugated
    Application
    • 7
    • 6
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    Specific for CACNA1I.
    Cross-Reactivity
    Human, Mouse, Rat
    Cross-Reactivity (Details)
    Other species not yet tested.
    Purification
    IgG
    Immunogen
    A synthetic peptide from a cytoplasmic domain of human CACNA1I conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
    Isotype
    IgG
    Top Product
    Discover our top product CACNA1I Primary Antibody
  • Application Notes
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Target
    CACNA1I (Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I))
    Alternative Name
    CACNA1I (CACNA1I Products)
    Synonyms
    CACNA1L antibody, Ca(V)3.3 antibody, Cav3.3 antibody, ca(v)3.3 antibody, si:ch211-51h13.1 antibody, Ca(v)3.3 antibody, calcium voltage-gated channel subunit alpha1 I antibody, voltage-dependent T-type calcium channel subunit alpha-1I antibody, calcium channel, voltage-dependent, alpha 1I subunit antibody, calcium channel, voltage-dependent, T type, alpha 1I subunit antibody, CACNA1I antibody, LOC100555412 antibody, Cacna1i antibody, cacna1i antibody
    Background
    Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H. Subcellular location: Membrane, Multi-pass membrane protein. Tissue specificity: Brain specific,Alpha Subunit,Voltage-dependent T-type calcium channel subunit alpha-1I, Voltage-gated calcium channel subunit alpha Cav3.3
    UniProt
    Q9P0X4
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