Calcium Channel, Voltage-Dependent, beta 2 Subunit (CACNB2) (C-Term) antibody

Antigen: Calcium Channel, Voltage-Dependent, beta 2 Subunit (CACNB2)

Synonyms: MYSB, CAVB2, CACNLB2, FLJ23743, Cchb2, AW060387, Cavbeta2, MGC129334, MGC129335, Cacnlb2, CACNB2, CAB2, Cacnb2, DKFZp468H0713

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350158

Additional Information

Alternative name: CACNB2 (CAB2, MYSB)

UniProt: Q08289

Immunogen: A synthetic peptide from the c-terminal region of human CACNB2 (CAB2, MYSB) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Isotype: IgG

Description: Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRS4). BRS4 is a heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Subcellular location: Cell membrane › sarcolemma; Peripheral membrane protein; Cytoplasmic side Tissue specificity: Expressed in all tissues. Also known as: Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B, MYSB, CACNLB2.

Specificity: Appears to be specific for CACNB2.

Application Details

Application Notes: IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.

Purity: IgG

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Rosenfeld, Wong, Dalmau et al.: "Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen." in: Annals of neurology, Vol. 33, Issue 1, pp. 113-20, 1993 (PubMed).

Taviaux, Williams, Harpold et al.: "Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23." in: Human genetics, Vol. 100, Issue 2, pp. 151-4, 1997 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Antzelevitch, Pollevick, Cordeiro et al.: "Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death." in: Circulation, Vol. 115, Issue 4, pp. 442-9, 2007 (PubMed).