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Details for Product No. ABIN350288

Desmin (DES) (C-Term) antibody

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Antigen
Synonyms CSM1, CSM2, LGMD2R, wu:fc11d08, zgc:154009, des-a, MGC52614, DES, des-b, MGC80853, des, csm1, csm2, desm, cmd1i, MGC75911, LOC100220724, desmin, cb290, fb59a12, wu:fb59a12, zgc:109859
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350288
Quantity 1000 µg
Price
454.67 $   Plus shipping costs $45.00
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Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen A synthetic peptide from c-terminal region of mouse Desmin conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in human and rat.
Isotype IgG
Specificity Appears to be specific for Desmin.
Purity IgG

Target Details

Application Details Handling References Alternatives back to top
Alternative Name Desmin
Background Function: Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Defects in DES are the cause of desmin-related cardio-skeletal myopathy (CSM), also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome).
Subcellular location: Cytoplasm. Also known as: Des.
UniProt P31001

Application Details

Target Details Handling References Alternatives back to top
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Format Lyophilized
Storage -20 °C

References

Target Details Application Details Handling Alternatives back to top
Li, Lilienbaum, Butler-Browne et al.: "Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development." in: Gene, Vol. 78, Issue 2, pp. 243-54, 1989 (PubMed).

Li, Choudhary, Milner et al.: "Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin." in: The Journal of cell biology, Vol. 124, Issue 5, pp. 827-41, 1994 (PubMed).

van Groningen, Bloemers, Swart: "Rat desmin gene structure and expression." in: Biochimica et biophysica acta, Vol. 1217, Issue 1, pp. 107-9, 1994 (PubMed).

Goldfarb, Park, Cervenáková et al.: "Missense mutations in desmin associated with familial cardiac and skeletal myopathy." in: Nature genetics, Vol. 19, Issue 4, pp. 402-3, 1998 (PubMed).

Goudeau, Dagvadorj, Rodrigues-Lima et al.: "Structural and functional analysis of a new desmin variant causing desmin-related myopathy." in: Human mutation, Vol. 18, Issue 5, pp. 388-96, 2001 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Desmin (DES)", type "Antibodies"
Hosts (129), (81), (7)
Reactivities (186), (75), (73), (44), (28), (25), (21), (8), (7), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Applications (143), (104), (56), (46), (34), (30), (19), (19), (16), (10), (3), (2), (2), (2), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (19), (13), (12), (12), (3), (3), (1), (1), (1), (1), (1), (1)
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