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Desmin (DES) (C-Term) antibody

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Antigen
Synonyms	ARVC7, ARVD7, CMD1I, CSM1, CSM2, MFM1, SCPNK, wu:fc11d08, zgc:154009, des-a, MGC52614, DES, des-b, MGC80853, des, csm1, csm2, desm, cmd1i, MGC75911, LOC100220724, desmin, cb290, fb59a12, MGC109859, wu ... show more ARVC7, ARVD7, CMD1I, CSM1, CSM2, MFM1, SCPNK, wu:fc11d08, zgc:154009, des-a, MGC52614, DES, des-b, MGC80853, des, csm1, csm2, desm, cmd1i, MGC75911, LOC100220724, desmin, cb290, fb59a12, MGC109859, wu:fb59a12, zgc:109859 show less
Epitope	Alternatives C-Term (19), (17), (16), (3), (3), (2), (1), (1), (1), (1)
Reactivity	Alternatives Mouse (Murine) (184), (97), (94), (33), (31), (28), (17), (7), (6), (6), (3), (3), (2), (1), (1)
Host	Alternatives Rabbit (129), (67), (5)
Clonality	Polyclonal
Conjugate	Alternatives Un-conjugated (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application	Alternatives Immunohistochemistry (IHC), Western Blotting (WB) (117), (74), (60), (54), (52), (22), (17), (13), (9), (9), (1), (1), (1)
	5 references available

Catalog no.	ABIN350288
Quantity	1000 µg
Price	454.67 $ Plus shipping costs $45.00

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Availability	Will be delivered in 7 to 8 Business Days

Product details

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Target Details

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Alternative Name	Desmin
Background	Function: Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Defects in DES are the cause of desmin-related cardio-skeletal myopathy (CSM); also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome). Subcellular location: Cytoplasm. Also known as: Des.
UniProt	P31001

Application Details

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Handling

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References

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Li, Lilienbaum, Butler-Browne et al.: "Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development." in: Gene, Vol. 78, Issue 2, pp. 243-54, 1989 (PubMed).

Li, Choudhary, Milner et al.: "Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin." in: The Journal of cell biology, Vol. 124, Issue 5, pp. 827-41, 1994 (PubMed).

van Groningen, Bloemers, Swart: "Rat desmin gene structure and expression." in: Biochimica et biophysica acta, Vol. 1217, Issue 1, pp. 107-9, 1994 (PubMed).

Goldfarb, Park, Cervenáková et al.: "Missense mutations in desmin associated with familial cardiac and skeletal myopathy." in: Nature genetics, Vol. 19, Issue 4, pp. 402-3, 1998 (PubMed).

Goudeau, Dagvadorj, Rodrigues-Lima et al.: "Structural and functional analysis of a new desmin variant causing desmin-related myopathy." in: Human mutation, Vol. 18, Issue 5, pp. 388-96, 2001 (PubMed).

Alternatives

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Alternatives for antigen "Desmin (DES)", type "Antibodies"

Hosts	(129), (67), (5)
Reactivities	(184), (97), (94), (33), (31), (28), (17), (7), (6), (6), (3), (3), (2), (1), (1)
Applications	(117), (74), (60), (54), (52), (22), (17), (13), (9), (9), (1), (1), (1)
Conjugates	(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes	(19), (17), (16), (3), (3), (2), (1), (1), (1), (1)

Immunogen	A synthetic peptide from c-terminal region of mouse Desmin conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in human and rat.
Isotype	IgG
Specificity	Appears to be specific for Desmin.
Purity	IgG

Application Notes	IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions	For Research Use only

Format	Lyophilized
Storage	-20 °C