Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) (AA 850-900) antibody

Details for Product No. ABIN350381
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Antigen
Synonyms erg, KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1, cerg, derg, erg1, ERG, AI326795, LQT, Lqt2, M-erg, Merg1, merg1a, merg1b, gp-erg
Epitope
AA 850-900
(14), (11), (4), (3), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine), Human
(61), (25), (23), (15), (12), (1)
Host
Rabbit
(65), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(53), (26), (19), (10), (8), (4), (4), (3), (3), (2), (1)
Pubmed 2 references available
Quantity 500 µg
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Catalog No. ABIN350381
454.67 $
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Immunogen A synthetic peptide from aa region 850-900 the of human KCNH2 conjugated to blue carrier protein was used as the antigen. The antigen is homologous in mouse and rat.
Isotype IgG
Specificity Specific for KCNH2.
Alternative Name KCNH2
Background Function: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Isoform 1 is expressed in heart, brain and testis and at low levels in lung. Isoform 3 is expressed predominantly in heart. The expression of isoform 2 is low in all tissues tested. Also known as: Potassium voltage-gated channel subfamily H member 2, Voltage-gated potassium channel subunit Kv11.1, Ether-a-go-go-related gene potassium channel 1, H-ERG, Erg1, Ether-a-go-go-related protein 1, Eag-related protein 1, eag homolog, ERG, ERG1, HERG, HERG1.
Research Area Cardiovascular
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Lees-Miller, Kondo, Wang et al.: "Electrophysiological characterization of an alternatively processed ERG K+ channel in mouse and human hearts." in: Circulation research, Vol. 81, Issue 5, pp. 719-26, 1997 (PubMed).

London, Trudeau, Newton et al.: "Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current." in: Circulation research, Vol. 81, Issue 5, pp. 870-8, 1997 (PubMed).

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