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Details for Product No. ABIN350436

LIM Domain Kinase 2 (LIMK2) (Internal Region) antibody

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Synonyms C85310, Limk2a, Limk2b, 9430059K01, A930024P04Rik, Link2, LIMK, xlimk2, zgc:91990, wu:fa97c09, wu:fk73e11, LIMK2
»Alternatives Internal Region
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350436
Quantity 500 µg
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the internal part of human LIMK2 (LIM domain kinase 2, LIMK-2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, mouse.
Isotype IgG
Specificity Appears to be specific for LIMK2.
Purity IgG
Alternative Name LIMK2 (LIM domain kinase 2, LIMK-2)
Background Function: Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Subcellular location: Cytoplasm. Nucleus. Note: Isoform LIMK2a is distributed in the cytoplasm and the nucleus, and isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.
Tissue specificity: Highest expression in the placenta, moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed. Also known as: LIM domain kinase 2, LIMK-2.
UniProt P53671
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Okano, Hiraoka, Otera et al.: "Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs." in: The Journal of biological chemistry, Vol. 270, Issue 52, pp. 31321-30, 1996 (PubMed).

Osada, Hasada, Inazawa et al.: "Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation." in: Biochemical and biophysical research communications, Vol. 229, Issue 2, pp. 582-9, 1997 (PubMed).

Maekawa, Ishizaki, Boku et al.: "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase." in: Science (New York, N.Y.), Vol. 285, Issue 5429, pp. 895-8, 1999 (PubMed).

Dunham, Shimizu, Roe et al.: "The DNA sequence of human chromosome 22." in: Nature, Vol. 402, Issue 6761, pp. 489-95, 1999 (PubMed).

Sumi, Matsumoto, Nakamura: "Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase." in: The Journal of biological chemistry, Vol. 276, Issue 1, pp. 670-6, 2001 (PubMed).

Alternatives for antigen "LIM Domain Kinase 2 (LIMK2)", type "Antibodies"
Hosts (84), (5), (4)
Reactivities (89), (56), (56)
Applications (82), (40), (37), (22), (15), (8), (5), (3), (2), (2), (2)
Epitopes (23), (13), (7), (7), (7), (6), (4), (2), (1), (1), (1), (1), (1)