LIMK2 Products
(LIM Domain Kinase 2 (LIMK2))
Categories
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured LIMK2 Categories
LIMK2 Antibodies
High quality antibodies with extensive validation data.
LIMK2 ELISA Kits
Reliable ELISA kits for a wide range of species.
LIMK2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LIMK2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (10)
Cat. No.
ABIN6256239
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN561676
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, IF
Validations
- (3)
Cat. No.
ABIN7138860
Quantity
100 μL
Datasheet
Datasheet
Recommended LIMK2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN5592316
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN2870021
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN6199768
Quantity
96 tests
Datasheet
Datasheet
Recommended LIMK2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5570605
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309440
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309442
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our LIMK2 products
: "LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission." in: Cell death and differentiation, Vol. 21, Issue 7, pp. 1036-49, (2014) (PubMed).: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin." in: The EMBO journal, Vol. 24, Issue 3, pp. 473-86, (2005) (PubMed).
: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).
: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).
: "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop." in: The Journal of biological chemistry, Vol. 275, Issue 5, pp. 3577-82, (2000) (PubMed).
: "The RET proto-oncogene in human cancers." in: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).
: "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics." in: Nature cell biology, Vol. 1, Issue 5, pp. 253-9, (1999) (PubMed).
Synonyms and alternative names related to LIMK2
LIM domain kinase 2 L homeolog (limk2.L), LIM domain kinase 2 (limk2), LIM domain kinase 2 (LIMK2), LIM domain kinase 2 (Limk2), LIM motif-containing protein kinase 2 (Limk2), 9430059K01, A930024P04Rik, C85310, LIMK, LIMK2, Limk2a, Limk2b, Link2, wu:fa97c09, wu:fk73e11, xlimk2, zgc:91990Protein level used designations for LIMK2
- XLIM-Kinases2
- LIM domain kinase 2
- LIM domain kinase 2-like
- LIM motif-containing protein kinase 2
- LIMK-2
- LIM kinase 2
- LIM-containing protein kinase 2a
- LIM-containing protein kinase 2t
- Limk2t-1 and Limk2t-2
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